Formate dehydrogenases are a set of enzymes that catalyse the oxidation of formate to carbon dioxide, donating the electrons to a second substrate, such as NAD + in formate:NAD+ oxidoreductase (EC 1.17.1.9) or to a cytochrome in formate:ferricytochrome-b1 oxidoreductase (EC 1.2.2.1). [1] .

Formate dehydrogenase (acceptor) (EC 1.1.99.33, FDHH, FDH-H, FDH-O, formate dehydrogenase H, formate dehydrogenase O) is an enzyme with systematic name formate:acceptor oxidoreductase. [1][2][3] This enzyme catalyses the following chemical reaction.

2021年8月1日 · Formate dehydrogenase (FDH) is a d -2‑hydroxy acid dehydrogenase, and catalyzes the oxidation of formate to carbon dioxide, coupled with reduction of NAD + to NADH that plays a key role in the process of NADH regeneration.

2024年7月24日 · Formate dehydrogenases (FDHs) catalyze the oxidation of formate to CO 2 while reducing NAD (P) + to NAD (P)H and are classified into two main classes: metal-dependent (Mo- or W-containing) and metal-independent FDHs.

2020年12月1日 · Formate dehydrogenase (FDH) has been known as an enzyme catalyzing nearly irreversible formate oxidation to CO2 for a long time [4], but recent research has revealed that certain FDHs are capable of reversibly interconverting CO 2 …

2023年9月1日 · Formate de­hydrogenases (FDHs) catalyze the two-electron oxidation of formate to carbon dioxide. FDHs can be divided into several groups depending on their subunit composition and active-site metal ions.

1998年1月17日 · Formate dehydrogenase H is a cytoplasmic enzyme that oxidizes formate without oxygen transfer, transferring electrons to a hydrogenase. The two enzymes form the formate-hydrogen lyase complex [1]. The enzyme contains an [4Fe-4S] cluster, a selenocysteine residue and a molybdopterin cofactor [1].

甲酸脱氢酶 (FDH) 是一种催化甲酸 (HCOO – )氧化为二氧化碳 (CO 2 ) 和水的酶，同时还原辅因子，如 NAD + （烟酰胺腺嘌呤二核苷酸）或 NADP + （黄素腺嘌呤）二核苷酸）。 这个过程产生能量，然后细胞可以将其用于各种代谢功能。 FDH 是关键的代谢酶，在许多细菌物种的能量产生、二氧化碳固定和氮代谢中发挥着关键作用。 FDH 是一种 D 特异性 2-羟基酸脱氢酶，主要存在于原核生物和真核生物中。 它对于通过氢负离子转移和生物转化为甲基热带生物提供能量至关重 …

Escherichia coli synthesizes a hydrogenase-linked formate dehydrogenase (FDHH) under anaerobic conditions in the absence of nitrate.

2022年9月14日 · Here we report cryo-EM structures of FHL in its aerobically and anaerobically isolated forms at resolutions reaching 2.6 Å. This includes well-resolved density for conserved loops linking the...