2020年6月4日 · Ferredoxin reductase (FDXR) is a mitochondrial membrane-associated flavoprotein. One of its functions is to transfer electrons from NADPH to the two human ferredoxin proteins,...

2022年10月24日 · Human mitochondria contain two isoforms of [2Fe-2S] ferredoxins, FDX1 (aka adrenodoxin) and FDX2, with known functions in cytochrome P450-dependent steroid transformations and Fe–S protein...

Human mitochondria contain two isoforms of [2Fe-2S] ferredoxins, FDX1 (aka adrenodoxin) and FDX2, with known functions in cytochrome P450-dependent steroid transformations and Fe–S protein biogenesis. Here, we show that only FDX2, but …

2024年12月25日 · FDXR (Ferredoxin Reductase) is a Protein Coding gene. Diseases associated with FDXR include Auditory Neuropathy And Optic Atrophy and Multiple Mitochondrial Dysfunctions Syndrome 9B. Among its related pathways are Metabolism of steroid hormones and Oxidation by cytochrome P450.

Here, we show that FDXR plays a role in tumorigenesis by modulating expression of the tumor suppressor p73. By using genetically modified mouse models, we recently showed that mice deficient in either Fdxr or Trp73 had a shorter lifespan and were prone to spontaneous tumors as compared with wild-type (WT) mice.

2023年9月1日 · Here we show that FDX1 directly regulates protein lipoylation by binding the lipoyl synthase (LIAS) enzyme promoting its functional binding to the lipoyl carrier protein GCSH and not through indirect regulation of cellular Fe-S cluster biosynthesis.

2021年8月15日 · Ferredoxin reductase (FDXR) or adrenodoxin reductase is a mitochondrial membrane-associated flavoprotein that transfers electrons from NADPH to cytochromes P450 through two electron carriers ferredoxin 1 (FDX1) and FDX2. FDXR is not only pivotal in steroidogenesis and biosynthesis of heme and iron–sulfur clusters [1, 2], but also contributes ...

2022年12月22日 · Our work reveals the divergent roles of FDX1 and FDX2 in mitochondria, identifies a role for FDX1 in lipoate synthesis, and suggests that loss of lipoic acid can be tolerated under low oxygen tensions in cell culture.

该基因编码一种线粒体黄素蛋白，它启动细胞色素 P450 的电子传输，从 NADPH 接收电子。 已发现该基因的多个选择性剪接转录物变体。 [RefSeq 提供，2012 年 4 月] This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

we identified a novel disease-causing gene FDXR associated with mitochondrial diseases. The biallelic FDXR mutations cause optic atrophy and neuropathy. we found that FDXR levels are significantly lower in the patient fibroblast cells with the homozygous mutations R392W.