2022年9月5日 · Furthermore, an effective colorimetric glutathione (GSH) sensor with a wide linear range from 0.02 µM to 250 µM and a detection limit as low as 9.3 nM was constructed based on the superior peroxidase-like activity of Fe 3 O 4 /N-HCS. The convenient colorimetric sensor monitored the content of GSH in the serum of mice, and the detection ...

2020年5月15日 · In this study, we designed a novel peanut probe that could load oxygen molecules and platinum (IV) prodrug (GINP-Pt) to elicit ferroptosis and apoptosis in cancer cells. In addition, transferrin-labeled amino polyethylene glycol (Tf-PEG-NH 2) was equipped to GINP-Pt to obtain targeting and pH-responsive ability.

16 小时之前 · The GO-Fe3O4 nanocomposites exhibit a dramatically enhanced Fenton reaction, showing a fourfold increase in catalytic effect compared to bare Fe3O4 nanoparticles. This is attributed to the synergistic peroxidase-like activity within the 3,3′,5,5′-tetramethylbenzidine (TMB)-hydrogen peroxide colorimetric system. ... (GSH), an antioxidant ...

2016年5月15日 · The magnetic molecularly imprinted polymers (MMIPs) based on Fe3 O 4 @Au-GSH showed good molecular recognition and excellent electrochemical activity of estradiol. The “soft modification” MMISF could be freely constructed or removed by using a controllable magnet, which avoided the complicated surface refreshing and modification of the electrodes.

2021年9月29日 · In vivo experiments have shown that Fe 3 O 4 nanoclusters can rapidly respond to overexpressed GSH in tumor sites for T 2 /T 1 switchable imaging. This work not only designed an endogenous GSH responsive platform through simple synthesis methods, but also improved the accuracy of tumor diagnosis through the transformation of T 2 / T 1 MRI signals.

2021年7月10日 · Herein for the first time, iron oxide nanoparticles are decorated using platinum nanocrystals (Fe3O4@Pt NPs) to integrate the current EDT with chemodynamic phenomenon and GSH depletion. Fe3O4@Pt NPs can effectively induce ROS generation based on the catalytic reaction on the surface of Pt nanoparticles triggered by electric field (E), and ...

Glutathione (GSH), the protective agent and reducing agent, has been widely used to prepare gold nanoclusters (GSH-Au NCs) with stable fluorescence properties and negative charge of the surface. Meanwhile, polyethyleneimine (PEI) was used as the modification agent to synthesize magnetic ferroferric oxide nanoparticles (Fe 3 O 4 ) with fantastic ...

5 天之前 · It was observed that without GSH only 1.1% of DOX was released while with GSH 54.8% of DOX was released. Hence it was concluded that a high GSH environment typically present in cancer cells favors the release of DOX. ... SW-626, PA-1, and HUVEC. IC50 value indicated Fe3O4@Thymbra spicata/Au NPs nanocomposite selectively targeted cancer cells ...

2025年2月20日 · The advent of nanozymes has revolutionized approaches to cancer diagnosis and therapy, introducing innovative strategies that address the limitations of conventional treatments. Nanozyme nanostructures with enzyme-mimicking catalytic abilities exhibit exceptional stability, biocompatibility, and customizable functions, positioning them as promising tools for cancer theranostics. By emulating ...

2021年12月16日 · Herein, a smart ultrasmall Fe 3 O 4-decorated polydopamine (PDA/Fe 3 O 4) hybrid nanozyme is demonstrated that continuously converts oxygen into highly toxic hydroxyl radical (•OH) via GSH-depleted cascade redox reactions for CDT-mediated bacterial elimination and intensive wound disinfection.