FeMoco (FeMo cofactor) is the primary cofactor of nitrogenase. Nitrogenase is the enzyme that catalyzes the conversion of atmospheric nitrogen molecules N 2 into ammonia (NH 3 ) through the process known as nitrogen fixation .

除了作为钼铁蛋白的专一性的电子供体外，铁蛋白还具有以下功能：参与钼铁蛋白M-簇(FeMoco)的生物合成，以及合成的FeMoco插入钼铁蛋白的过程，并且可能对固氮酶体系的表达具有调控功能。

2016年3月14日 · The [Mo:7Fe:9S:C] iron-molybdenum cofactor (FeMoco) of nitrogenase is the largest known metal cluster and catalyses the 6-electron reduction of dinitrogen to ammonium in biological nitrogen...

铁钼辅因子 （FeMo 辅因子 、FeMoco）是以 固氮酶 为核心的 辅因子， 化学式 为 Fe 7 MoS 9 C。 固氮酶在 固氮过程 中負責将大气中的 氮气 催化转化为 氨气（NH 3），其含有金属 铁 及 钼 的辅因子。 铁钼辅因子作为 原子簇，可被視為两個部分团簇的组合：Fe 4 S 3 团簇和MoFe 3 S 3 团簇。 两組子团簇通过三个硫（II）配体相连。 其中，Fe通过 半胱氨酸 （Cys）连接到 固氮酶，並與其余的三个 硫 原子相互键合形成 四面体的局部分子结构。 其余六个Fe原子在分子团 …

该酶使用独特的过渡金属-硫-碳簇作为其 活性位点 辅助因子（[(R-homocitrate)MoFe7S9C], FeMoco)，并且假定硫包围的铁 (Fe) 原子捕获和还原N2。迄今为止，虽然有几种合成的 FeMoco/金属硫簇对应物例子显示出可以与 N2 结合，但是，所合成的金属硫簇或提取形式的 …

2022年7月6日 · Although the detailed N 2-reduction mechanism of FeMoco remains elusive, a growing number of studies suggest that FeMoco eliminates one of the µ 2-bridging sulfur (S) atoms and captures ...

2019年7月29日 · The size and complexity of Mo-dependent nitrogenase, a multicomponent enzyme capable of reducing dinitrogen to ammonia, have made a detailed understanding of the FeMo cofactor (FeMoco) active site electronic structure an ongoing challenge.

Biological nitrogen fixation is enabled by molybdenum-dependent nitrogenase enzymes, which effect the reduction of dinitrogen to ammonia using an Fe7MoS9C active site, referred to as the iron molybdenum cofactor or FeMoco. In this mini-review, we summarize the current understanding of the molecular and electronic structure of FeMoco.

Biosynthesis of nitrogenase FeMoco is a highly complex process that requires, minimally, the participation of nifS, nifU, nifB, nifE, nifN, nifV, nifH, nifD and nifK gene products. Previous genetic analyses have identified the essential factors for ...

The active site of the molybdenum-dependent nitrogenase is the unique carbide-containing iron-sulfur cluster called the iron-molybdenum cofactor (FeMoco). On the FeMoco, N 2 binding is suggested to occur at one or more iron atoms, but the structures of …