The drug combination fenfluramine/phentermine, usually called fen-phen, is an anti-obesity medication that is no longer widely available. It was sold in the early 1990s, and utilized two anorectics.

Fenfluramine, sold under the brand name Fintepla, is a serotonergic medication used for the treatment of seizures associated with Dravet syndrome and Lennox–Gastaut syndrome. [3][7][4] It was formerly used as an appetite suppressant in the treatment of obesity, but was discontinued for this use due to cardiovascular toxicity before being repurpo...

The recently described cardiac valvulopathy attributed to the appetite-suppressant drugs fenfluramine and phentermine (fen-phen)1 took the medical community and the public by surprise.

1997年8月28日 · We identified valvular heart disease in 24 women treated with fenfluramine–phentermine who had no history of cardiac disease. The women presented with cardiovascular symptoms or a heart...

2000年5月2日 · These findings suggest that fenfluramine-phentermine–associated valve regurgitation primarily involves patients who were treated for >6 months and predominantly results in mild grades of aortic regurgitation not associated with clinical sequelae during the study period.

2000年4月1日 · Phentermine was previously used in combination with fenfluramine (Pondimin) to improve weight loss and counteract the adverse effects of use of phentermine. Because of the withdrawal of...

Phentermine had been used in combination with fenfluramine. The combination therapy demonstrated significantly more weight loss than a placebo in a 28-week RCT (15.5% vs. 4.9%, P<0.001). However, fenfluramine was withdrawn from the market by the U.S. FDA in 1997 .

Phentermine is the safe half of the phentermine-fenfluramine (phen-fen) combination therapy introduced in the 1990s.

1999年9月30日 · Fenfluramine is a fluorinated amphetamine derivative believed to lack the psychomotor stimulant effects and abuse potential traditionally recognized with amphetamines. 44 Fenfluramine’s activity is mediated through serotonergic pathways by promoting release of serotonin and inhibiting its reuptake. 44,45 Phentermine is a noradrenergic drug ...

Compare Fenfluramine vs Phentermine head-to-head with other drugs for uses, ratings, cost, side effects and interactions.