In the acute phase response, there are changes in the concentration of a number of plasma proteins, called acute phase reactants (APR); these changes are thought to contribute to host defense and adaptive capabilities [4].

Serum ferritin is widely recognized as an acute phase reactant and marker of acute and chronic inflammation, and is nonspecifically elevated in a wide range of inflammatory conditions, including chronic kidney disease, rheumatoid arthritis and other autoimmune disorders , …

All forms of inflammation, regardless of its cause, may elevate ferritin levels, and are thus recognized as an acute phase reactant. Pro-inflammatory cytokines stimulate the synthesis of ferritin and hepcidin, leading to hyperferritinemia, iron retention in macrophages, and less iron being available for erythropoiesis due to the redistribution ...

2023年4月24日 · Positive acute phase reactants include procalcitonin, C-reactive protein, ferritin, fibrinogen, hepcidin, and serum amyloid A. Negative acute phase reactants include albumin, prealbumin, transferrin, retinol-binding protein, and antithrombin.

Under normal circumstances, serum ferritin levels are a sensitive marker for iron status but ferritin is an acute-phase reactant that becomes elevated in response to inflammation, complicating the diagnosis.

2020年9月17日 · Ferritin is an intracellular iron storage protein whose levels are indicative of the body's total iron stores. An elevated ferritin is classically a marker of iron overload, however ferritin is also an acute phase reactant and may be elevated in the context of acute inflammation.

Ferritin is a positive acute phase reactant, exhibiting increased levels in blood during the acute phase response. Nevertheless, the precise role of ferritin as an acute phase reactant remains to be clarified. As for other acute phase proteins, ferritin is produced and secreted by hepatocytes.

2008年1月1日 · Tentative conclusions are drawn concerning the inter-relationships between ferritin and the acute phase proteins, C-reactive protein and α-1-acid glycoprotein during an acute phase response. Iron deficiency is the most common micronutrient deficiency in the world, but its detection is often obscured by infections.

2021年10月4日 · Ferritin is a cellular iron storage protein and an acute phase reactant; Transferrin saturation testing can identify iron overload states; Ferritin elevations above 10 000 μg/L should prompt consideration of specific diagnoses; Patient history and examination should guide additional investigations

Acting as an acute phase reactant, ferritin sequesters and stores iron intracellularly. The role of ferritin in iron homeostasis in the context of inflammation has a great importance in body protection against infection, injury, and cancer.