Autophagy promotes ferroptosis by degradation of ferritin
2016年8月2日 · Here, we demonstrated that autophagy contributes to ferroptosis by degradation of ferritin in fibroblasts and cancer cells. Knockout or knockdown of Atg5 (autophagy-related 5) …
The molecular and metabolic landscape of iron and ferroptosis in ...
2022年7月4日 · This study demonstrates that ferritin has a major role in protecting against cardiac ferroptosis and suggests SLC7A11 as a potential new therapeutic target for cardiomyopathy …
The Role of Ferritin in Health and Disease: Recent Advances and ...
Ferritin is the intracellular iron storage protein that stores surplus iron after all the cellular needs are fulfilled and releases it in the face of an acute demand. Currently, there is a surge in …
Ferroptosis: mechanisms and therapeutic targets - PMC
In this review, we first elucidate core mechanisms of ferroptosis and summarize its epigenetic modifications (e.g., histone modifications, DNA methylation, noncoding RNAs, and …
Iron Metabolism in Ferroptosis - PMC - PubMed Central (PMC)
In addition to cytosolic ferritin, the overexpression of mitochondrial ferritin (FTMT) in neuronal cells inhibits erastin-induced ferroptosis and increases the cellular labile iron pool (Wang et al., 2016).
Ferroptosis: iron release mechanisms in the bioenergetic process
2025年2月25日 · Ferroptosis, an iron-dependent form of cell death, has been the focus of extensive research over the past decade, leading to the elucidation of key molecules and …
Ferroptotic mechanisms and therapeutic targeting of iron …
2023年3月15日 · With the capacity to accept and donate electrons, iron cycles between ferrous [Fe (ii)] and ferric [Fe (iii)] forms, enabling proper functioning of many non-haem and haem …
Ferroptosis: mechanisms, biology and role in disease
2021年1月25日 · In this Review, we provide a critical analysis of the current molecular mechanisms and regulatory networks of ferroptosis, the potential physiological functions of …
Mechanisms of Ferritinophagy and Ferroptosis in Diseases
2023年9月22日 · Ferritinophagy and ferroptosis are implicated in the regulation of multiple diseases, including neurological diseases, cardiovascular diseases, breast cancer, liver …
Ferroptosis: principles and significance in health and disease
2024年6月6日 · Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid peroxidation, is governed by molecular networks involving diverse molecules and organelles.