Recent progress in ferroptosis: inducers and inhibitors
2022年12月29日 · Ferrostatin-1 (Fer-1) was identified as a ferroptosis inhibitor by Dixon et al. in 2012, which was proved to inhibit RSL3 or erastin induced ferroptosis in HT-1080 cells.
Ferroptosis: past, present and future - Cell Death & Disease
2020年2月3日 · The application of the ferroptosis inhibitor Fer-1 significantly reduces iron deposition, neuronal degeneration, and injury and improves the prognosis of patients, thus …
Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors
2023年12月1日 · In this Review, we provide a comprehensive overview of the different classes of ferroptosis inhibitors, focusing on endogenous and synthetic RTAs. A thorough analysis of …
Ferroptosis inhibitors: past, present and future - Frontiers
2024年5月6日 · Acting on ferroptosis-related targets may provide new strategies for the treatment of ferroptosis-mediated diseases. This article specifically describes the metabolic pathways of …
Ferroptosis inhibitors: past, present and future - PubMed
2024年5月23日 · Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have …
Targeting ferroptosis opens new avenues for the development of …
2023年9月21日 · With respect to cancer, novel ferroptosis agonists have shown promise in several cancer types. On the other hand, antagonists of ferroptosis have been shown to help …
Recent progress in ferroptosis: inducers and inhibitors
2022年12月29日 · This paper briefly introduces important regulatory targets in the ferroptosis metabolic pathway, lists and categorizes commonly used and recently developed inducers and …
Ferroptosis Inhibitors as Potential New Therapeutic Targets for ...
The iron, lipid, amino acid, and glutathione metabolisms strictly govern the beginning and execution of ferroptosis. Therefore, ferroptosis can be inhibited by iron chelators, free radical …
Identifying eleven new ferroptosis inhibitors as neuroprotective …
2024年5月1日 · In this study, we identified ferroptosis inhibitors as neuroprotective agents from US Food and Drug Administration (FDA)-approved drugs. 1176 drugs have been screened …
Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo ...
2018年10月25日 · Novel inhibitors derived from the Fer-1 scaffold inhibited ferroptosis potently but suffered from solubility issues. In this paper, we report the synthesis of a more stable and …
Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors
2023年9月26日 · In this Review, we provide a comprehensive overview of the different classes of ferroptosis inhibitors, focusing on endogenous and synthetic RTAs. A thorough analysis of …
Ferroptosis Inhibition: Mechanisms and Opportunities
2017年5月1日 · We review here advances in our understanding of the ferroptotic process and summarize the development of lipid peroxidation inhibitors with the ultimate goal of …
Advances in understanding ferroptosis mechanisms and their
2025年2月10日 · 4.1 The dual role of ferroptosis in tumour treatment. Ferroptosis is a double-edged sword in tumour treatment. On the one hand, AKR1C2 inhibits ferroptosis by degrading …
Ferroptosis Inhibition: Mechanisms and Opportunities - Cell …
2017年3月28日 · We review here advances in our understanding of the ferroptotic process and summarize the development of lipid peroxidation inhibitors with the ultimate goal of …
Ferroptosis: mechanism and role in diabetes-related …
2025年2月7日 · The ferroptosis inhibitor ferrostatin-1, effectively attenuated diabetic atherosclerosis and mitigated HFD-induced lipid metabolism disorder in diabetic mice with …
Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors
In this Review, we provide a comprehensive overview of the different classes of ferroptosis inhibitors, focusing on endogenous and synthetic RTAs. A thorough analysis of their chemical, …
Ferroptosis turns 10: Emerging mechanisms, physiological …
2022年7月7日 · Ferroptosis has been implicated in a broad set of biological contexts, from development to aging, immunity, and cancer. This review describes key regulators of this form …
Epigenetic Regulation and Nonepigenetic Mechanisms of Ferroptosis …
2021年1月29日 · PdPT is an inhibitor of DUBs, including USP7, USP10, USP14, USP15, USP25, and UCHL5. These inhibitors activate caspase-dependent apoptosis and GPX4-degradation …
Tungsten-based polyoxometalate nanoclusters as ferroptosis inhibitors ...
2025年2月19日 · Here, we explored the potential of tungsten-based polyoxometalate (W-POM) NCs as ferroptosis inhibitors targeting the iron metabolic pathway mediated by S100A8/A9 for …
Novel Ferroptosis Inhibitors with Improved Potency and ADME …
2015年12月22日 · In this study, we report the synthesis of novel ferroptosis inhibitors containing amide and sulfonamide moieties with improved stability, single digit nanomolar antiferroptotic …
Scientists Build Ferroptosis Inhibitors to Curb Cell Death Process ...
2023年11月20日 · The team tested two pocket-filling ferroptosis inhibitors: FerroLOXIN-1 and FerroLOXIN-2. Both prevented formation of 15LOX-2/PEBP1’s telltale oxidized lipid in human …
Cancer cells avoid ferroptosis induced by immune cells via fatty …
2025年2月3日 · Tumors resistant to immunotherapy have altered lipid metabolic profiling to avoid ferroptosis. A Mass spectrometry-based lipidomics profiling of PD1-sensitive (Sen) and PD1 …
Identifying eleven new ferroptosis inhibitors as ... - PubMed
In this study, we identified ferroptosis inhibitors as neuroprotective agents from US Food and Drug Administration (FDA)-approved drugs. 1176 drugs have been screened against erastin …
EZH2 suppresses IR-induced ferroptosis by forming a co ... - Nature
2025年2月7日 · Finally, to obtain more convincing evidence regarding the role of EZH2 in modulating ferroptosis in KDM6A-deficient ESCC cells, we evaluated the effects of various …
USP9X suppresses ferroptosis in diabetic kidney disease by ...
2025年2月18日 · For example, ferroptosis exhibits a considerable role in acute renal injury caused by ischemia-reperfusion and DKD and is also one of the pathogenic factors ... or Nrf2 …
Ferroptosis Inhibition: Mechanisms and Opportunities
We review here advances in our understanding of the ferroptotic process and summarize the development of lipid peroxidation inhibitors with the ultimate goal of suppressing ferroptosis …
Nanozyme as tumor energy homeostasis disruptor mediated ferroptosis …
2025年2月18日 · The CCK-8 assay was employed to assess cell viability following treatment with the ferroptosis inhibitor Fer-1. As shown in Fig. 6 D, pre-treatment with Fer-1 caused a …