A hallmark of FGFRs is the presence of an acidic, serine-rich sequence in the linker between D1 and D2, termed the acid box. The D2–D3 fragment of the FGFR ectodomain is necessary and sufficient for ligand binding and specificity, whereas the D1 domain and the acid box are proposed to have a role in receptor autoinhibition 15 (FIG. 2a).

1974年，英国科学家Gospodarowicz从牛的脑垂体中首次分离出能促进成纤维细胞生长的物质，将其命名为 成纤维细胞生长因子 （Fibroblast Growth Factor, FGF）。 FGFs在细胞增殖、组织修复和再生、血管生成中扮演着重要作用。 FGF关联的信号通路会影响细胞增殖、细胞迁移、细胞分化等生物学过程。 FGFs基因突变与癌症、心血管疾病、骨关节炎、糖尿病、帕金森病和低磷酸盐血症等多种疾病有关。

FGF（Fibroblast Growth Factor，成纤维细胞生长因子）是一类多肽生长因子家族，目前发现至少有23个不同成员，参与发育、分化、细胞存活、迁移、血管生成和致癌作用。

2010年2月1日 · The FGF signalling pathway comprises 4 highly conserved transmembrane receptors and 18 FGF ligands (Box 1). FGFs bind with low affinity to cell surface HSPGs (purple) and with high affinity...

Between receptor protein Domains D1 and D2 is a short span of acidic residues called the "acid box." A cartoon schematic of FGF Receptor Domains is shown below: FGF Receptor Domains.

In this review we will focus on the roles and regulation of FGF signaling pathways that function during vertebrate organogenesis and on how gain and loss-of-function mutations in the FGF pathway result in developmental or metabolic disease and cancer.

2019年4月21日 · The FGF signalling pathway comprises 4 highly conserved transmembrane receptors and 18 FGF ligands (Box 1). FGFs bind with low affinity to cell surface HSPGs (purple) and with high affinity to specific FGFRs.

2006年11月17日 · In the context of the FGFR, our results demonstrate that whereas the CAM homology domain is dispensable for the CAM/FGFR interactions, the proximal acid box region is absolutely required. Interestingly, the acid box can be spliced out of the FGFR and is not required for FGF function (26).

The amino acid sequences (FastA) for the human FGF receptors were downloaded from the appropriate NCBI Entrez entry and aligned with Clustal X. Following each alignment is a table showing the sequence associated with the protein domains of the receptor.

FGF与FGFR结合，调控下游信号通路，在促分裂（胚胎发生、生长发育等）和非促分裂（神经调节、代谢调节等）均其中重要的作用。 FGFR的高表达、突变等会导致信号通路的异常激活，FGFR通路促分裂作用不受控制，导致肿瘤的发生。