FGFs are cell growth factors involved in multiple critical pathophysiologic processes in the human body via paracrine and autocrine pathways such as embryonic development and angiogenesis, neurogenesis, wound healing, and glucolipid metabolism, which need to bind fibroblast growth factors receptor (FGFR) to produce physiological effects (Hui et ...

成纤维细胞生长因子FGF（Fibroblast Growth Factors，FGFs）最初是以其成纤维细胞的有丝分裂能力命名的。 FGF及其受体在动物界高度保守。 在哺乳动物中，FGF家族包括23种多肽，它们调节多种细胞的迁移、增殖、分化、…

1974年，英国科学家Gospodarowicz从牛的脑垂体中首次分离出能促进成纤维细胞生长的物质，将其命名为 成纤维细胞生长因子 （Fibroblast Growth Factor, FGF）。 FGFs在细胞增殖、组织修复和再生、血管生成中扮演着重要作用。

The fibroblast growth factor (FGF) family of proteins includes signalling proteins secreted by tissues to regulate cell metabolism, proliferation, differentiation, and survival. The biological functions and endogenic roles of FGFs in tissue development and …

FGF通过与 成纤维细胞生长因子受体 （FGFR）介导的信号轴刺激或维持代谢、组织稳态和发育所需的特定细胞功能，主要调节细胞增殖，分化，存活，迁移和代谢。 哺乳动物FGF家族由22种相关成员组成，所有成员都具有大约140个氨基酸的核心区段，根据氨基酸序列和结构分析，其中18个被分为 五个旁分泌作用组（FGF1、FGF4、FGF7、FGF8、FGF9亚家族） 和 一个内分泌作用组（FGF19亚家族），另外还有 一个细胞内非分泌作用组（FGF11亚家族） (Figure 1)。 …

2018年7月18日 · Since FGF family shares several similar signaling pathways and there is no study addressing on the effects of FGF9 on HD, we hypothesize FGF9 might also provide neuroprotective functions in HD. In this study, we used HD striatal cell lines to investigate the effects of FGF9, and showed the anti-apoptotic functions dominantly through the ...

2001年2月3日 · Fibroblast growth factors (FGFs) make up a large family of polypeptide growth factors that are found in organisms ranging from nematodes to humans. In vertebrates, the 22 members of the FGF family range in molecular mass from 17 …

成纤维细胞生长因子（fibroblast growth factor,FGF）有几种异构体，在动脉硬化灶中起作用的主要是bFGF（basic fibroblast growth factor），bFGF可以由内皮细胞、平滑肌细胞、巨噬细胞分泌。

Fibroblast growth factors (FGF) are a family of cell signalling proteins produced by the macrophages. They are involved in a wide variety of processes, most notably as crucial elements for normal development in animal cells. Any irregularities in their function will lead to a range of developmental defects.

2023年5月5日 · FGFs are cell growth factors involved in multiple critical pathophysiologic processes in the human body via paracrine and autocrine pathways such as embryonic development and angiogenesis, neurogenesis, wound healing, and glucolipid metabolism, which need to bind fibroblast growth factors receptor (FGFR) to produce physiological effects (Hui et ...