Intrahepatic cholangiocyte regeneration from an Fgf-dependent ...
Fgf signaling directly maintains progenitors in the EHD niche by preventing their premature differentiation and allocation into the liver. Our discovery of quiescent progenitors residing in …
Intrahepatic cholangiocyte regeneration from an Fgf-dependent ...
Tissue-specific mosaic analysis with an inducible dominant-negative Fgf receptor suggests that Fgf signaling from the surrounding mesenchymal cells maintains this extrahepatic niche by …
Conclusions: Our data show that IHD cells regenerate upon resumption of Jagged/Notch signaling, from multipotent progenitors originating from an Fgf-dependent extrahepatic stem …
Intrahepatic cholangiocyte regeneration from an Fgf …
Alagille Syndrome (ALGS) is a congenital disorder caused by mutations in the Notch ligand gene JAGGED1, leading to neonatal loss of intrahepatic duct (IHD) cells and cholestasis. …
Intrahepatic cholangiocyte regeneration from an Fgf-dependent ...
2022年3月2日 · Our data show that IHD cells regenerate upon resumption of Jag/Notch signaling, from multipotent progenitors originating from an Fgf-dependent extrahepatic stem cell niche. …
Hepatology：在肝脏外发现了一种新的肝脏干细胞来源，有望治疗Alagille综合征 …
2021年10月13日 · 肝外胆管中的祖细胞（EHD祖细胞）在Notch信号消失时发生增殖并迁移到肝脏，如果Notch信号增加，则分化为IHD细胞。用诱导性显性阴性Fgf受体进行的 ...
Intrahepatic cholangiocyte regeneration from an Fgf-dependent ...
Our data show that IHD cells regenerate upon resumption of Jagged/Notch signaling, from multipotent progenitors originating from an Fgf-dependent extrahepatic stem cell niche. We …
了不起的成纤维细胞生长因子(FGF)家族 - 知乎 - 知乎专栏
成纤维细胞生长因子FGF（Fibroblast Growth Factors，FGFs）最初是以其成纤维细胞的有丝分裂能力命名的。 FGF及其受体在动物界高度保守。 在哺乳动物中，FGF家族包括23种多肽，它 …
Intrahepatic cholangiocyte regeneration from an Fgf‐dependent ...
Our data show that IHD cells regenerate upon resumption of Jagged/Notch signaling, from multipotent progenitors originating from an Fgf‐dependent extrahepatic stem cell niche. We …
FGFR：信号通路与靶向药物 - 知乎 - 知乎专栏
1974年，英国科学家Gospodarowicz从牛的脑垂体中首次分离出能促进成纤维细胞生长的物质，将其命名为 成纤维细胞生长因子 （Fibroblast Growth Factor, FGF）。 FGFs在细胞增殖、组织 …