Molecular and clinical studies revealed that iron deficiency, through several mechanisms, alters FGF23 at the transcriptional and post-translational level. This review will focus upon the novel discoveries elucidated between iron, its regulators, and their influence on FGF23 bioactivity.

Ferro-grad F® contains iron and folic acid for the prevention and treament of tiredness and fatigue, associated with iron deficiency in pregnancy.

FGF23 regulates inflammatory responses, iron status, and erythropoiesis, and blocking FGF23 activity rescues anemia and iron deficiency, attenuates inflammation, improves renal dysfunction, and prevents renal fibrosis in mice with renal impairment, suggesting a …

In the present study, we found that iron overload promoted ferroptosis in hepatocytes by excessively inducing HO-1 expression, which contributed to the progression of liver injury and fibrosis, accompanied by the upregulation of the FGF21 protein level in vitro and in vivo.

2019年9月4日 · Iron administration (especially iron carboxymaltose) may inhibit the cleavage of fibroblast growth factor-23 (FGF23), with an increase of the circulating active hormone iFGF23. cFGF23, C-terminal fibroblast growth factor-23; HIF-α1, hypoxia inducible factor-alpha1; iFGF23, intact fibroblast growth factor-23.

2019年9月13日 · Fibroblast growth factor 23 (FGF23) was initially characterized as an important regulator of phosphate and calcium homeostasis. New research advances demonstrate...

Iron deficiency was associated with markedly elevated cFGF23 (807.8 ± 123.9 relative units [RU]/mL) but normal iFGF23 (28.5 ± 1.1 pg/mL) levels at baseline. Within 24 hours of iron administration, cFGF23 levels fell by approximately 80% in both groups.

2016年3月17日 · Fibroblast growth factor 23 (FGF-23) levels are elevated in impaired renal function. Inflammation and iron are potential regulators of FGF-23. The aim of the study was to evaluate the association between FGF-23 concentration, novel iron status biomarkers and inflammatory parameters among patients with early stages of chronic kidney disease (CKD).

2023年7月6日 · Bone-derived Cter-FGF23 peptides are iron conserving molecules and antagonize BMP-induced hepcidin production. Inflammation leads to functional iron deficiency by increasing the expression of the hepatic iron regulatory peptide hepcidin.

Inflammation and iron are potential regulators of FGF-23. The aim of the study was to evaluate the association between FGF-23 concentration, novel iron status biomarkers and inflammatory parameters among patients with early stages of chronic kidney disease (CKD).