2018年9月1日 · As central modulators of FGF signaling with known roles at the NMJ, it is reasonable to posit that FGFBPs play important functions in the CNS affected by diseases, the normal aging process, and following injury.

This pathway drives the clustering of acetylcholine receptors (AChRs) to ensure efficient signal transduction at the NMJ. We also discuss three secreted molecules (Rspo2, Fgf18, and connective tissue growth factor (Ctgf)) that we recently identified in the Wnt/β-catenin and fibroblast growth factors (FGF) signaling pathways.

2023年12月19日 · Initial exposure of hPSCs to WNT agonist (CHIR) and basic FGF (bFGF) signals for three days resulted in the efficient generation of NMP cells that co-expressed the nascent mesodermal marker ...

2018年1月11日 · We propose that FGF18 plays a pivotal role in AChR clustering and NMJ formation in mouse embryogenesis. FGF receptor 2 is involved in the formation of the neuromuscular junction (NMJ), but...

2023年10月16日 · The FGF system is also important for neuromuscular junction (NMJ) formation. Umemori and colleagues showed that FGF22 promotes synapse formation in motor neurons by inducing redistribution of synaptic vesicle components, particularly synapsin and SV2.

2025年2月19日 · Silencing FGF21 in muscle prevents denervation-induced muscle wasting by preserving neuromuscular junction (NMJ) innervation. Conversely, forced expression of FGF21 in muscle reduces NMJ innervation, leading to muscle atrophy.

2012年2月13日 · Several models of SMA show deficits in neurite outgrowth and maintenance of neuromuscular junction (NMJ) structure. Survival of motoneurons, axonal outgrowth and formation of NMJ is controlled by neurotrophic factors such as the Fibroblast Growth Factor (FGF) system.

Striated muscles from Drosophila and several vertebrates extend plasma membrane to facilitate the formation of the neuromuscular junction (NMJ) during development. However, the regulation of these membrane extensions is poorly understood. In C. elegans, the body wall muscles (BWMs) also have plasma …

As central modulators of FGF signaling with known roles at the NMJ, it is reasonable to posit that FGFBPs play important functions in the CNS affected by diseases, the normal aging process, and following injury. Accordingly, Bachis et al. found that both FGF2 and FGFBP1 levels increase in the brains of rats treated with anti­depressants ...

In addition, it was proven that the regulatory activity of FGF on Ras/MAPK via SOS/Grb2 and Stump seems particularly important for the correct neuromuscular junction (NMJ) formation during ...