FGF-3 is a member of the fibroblast growth factor family. FGF3 binds to Fibroblast Growth Factor Receptor 3 (FGFR3) to serve as a negative regulator of bone growth during ossification. Effectively, FGF-3 inhibits proliferation of chondrocytes within growth plate.

2024年12月25日 · FGF3 (Fibroblast Growth Factor 3) is a Protein Coding gene. Diseases associated with FGF3 include Deafness, Congenital, With Inner Ear Agenesis, Microtia, And Microdontia and Deafness With Labyrinthine Aplasia, Microtia, And Microdontia. Among its related pathways are Downstream signaling of activated FGFR2 and Insulin receptor signalling cascade.

Fibroblast growth factor receptor 3 (FGFR-3) is a protein that in humans is encoded by the FGFR3 gene. [5] FGFR3 has also been designated as CD333 (cluster of differentiation 333). The gene, which is located on chromosome 4, location p16.3, is expressed in tissues such as the cartilage, brain, intestine, and kidneys. [6]

已鉴定出四种独立基因编码的成纤维细胞生长因子受体（FGFRs）：FGFR1、FGFR2、FGFR3和FGFR4。 他们是跨膜酪氨酸激酶受体，通过硫酸乙酰肝素或Klotho依赖性途径介导FGF信号转导。 这些FGFRs是单链糖蛋白，由胞外区、跨膜区和胞内区组成。 FGFRs的胞外区域包含三个免疫球蛋白样结构域（D1-D3），在D1和D2结构域之间有一个富含丝氨酸的酸盒。 跨膜区为跨膜螺旋，胞内区为酪氨酸激酶区（图1B）。 另外，还有FGFR家族的第五个成员FGFR …

The FGF3 gene provides instructions for making a protein called fibroblast growth factor 3 (FGF3). This protein is part of a family of proteins called fibroblast growth factors that are involved in important processes such as cell division, regulation of cell growth and maturation, formation of blood vessels, wound healing, and development ...

成纤维细胞生长因子 3： 该基因编码的蛋白质是成纤维细胞生长因子 (fgf) 家族的成员。 FGF 家族成员具有广泛的促有丝分裂和细胞存活活性，并参与多种生物过程，包括胚胎发育、细胞生长、形态发生、组织修复、肿瘤生长和侵袭。

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.

2001年2月3日 · Fibroblast growth factors (FGFs) make up a large family of polypeptide growth factors that are found in organisms ranging from nematodes to humans. In vertebrates, the 22 members of the FGF family range in molecular mass from 17 …

2025年2月8日 · The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.

2025年1月4日 · The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.