The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified ...

FGF-4 Protein, Human是一种成纤维细胞生长因子 (FGF)，能够高效地转化 3T3 细胞，刺激内皮细胞增殖，迁移和蛋白酶的产生，具有心血管生成的活性。 FGF-4 蛋白协调胚胎发育、细胞增殖和分化，对于正常肢体和心脏瓣膜发育至关重要。 FGF-4可能通过诱导关键基因表达来促进胚胎磨牙牙芽发育。 Animal-Free FGF-4 Protein, Human (His) 是重组的 无动物源 FGF-4 蛋白，由 E. coli 表达，带有 C-His 标签。 FGF-4 蛋白协调胚胎发育、细胞增殖和分化，对于正常肢体和心脏瓣 …

成纤维细胞生长因子FGF（Fibroblast Growth Factors，FGFs）最初是以其成纤维细胞的有丝分裂能力命名的。 FGF及其受体在动物界高度保守。 在哺乳动物中，FGF家族包括23种多肽，它们调节多种细胞的迁移、增殖、分化、…

2024年12月25日 · FGF4 (Fibroblast Growth Factor 4) is a Protein Coding gene. Diseases associated with FGF4 include Embryonal Carcinoma and Germ Cell Cancer. Among its related pathways are Downstream signaling of activated FGFR2 and Apoptotic Pathways in …

The fibroblast growth factor-4 (FGF-4) gene was identified as HST-1 gene from human stomach cancers and Kaposi’s sarcoma by a NIH3T3 transforming assay. FGF-4 has pleiotropic roles in many cell types and tissues, it is a mitogenic, angiogenic and survival factor, which is involved in cell proliferation and differentiation and in a variety of ...

fgf-4通过硫酸乙酰肝素依赖性路径传递信号，可激活配体fgfr（与fgfr4结合特异性最强）启动损伤修复、器官再生和代谢调控 。在人胚胎发育过程中，fgf-4助力干细胞的自我更新与胚胎磨牙芽的发育。

已鉴定出四种独立基因编码的成纤维细胞生长因子受体（FGFRs）：FGFR1、FGFR2、FGFR3和FGFR4。 他们是跨膜酪氨酸激酶受体，通过硫酸乙酰肝素或Klotho依赖性途径介导FGF信号转导。 这些FGFRs是单链糖蛋白，由胞外区、跨膜区和胞内区组成。 FGFRs的胞外区域包含三个免疫球蛋白样结构域（D1-D3），在D1和D2结构域之间有一个富含丝氨酸的酸盒。 跨膜区为跨膜螺旋，胞内区为酪氨酸激酶区（图1B）。 另外，还有FGFR家族的第五个成员FGFR …

2025年1月4日 · The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.

Gibco™ Human FGF-4 Protein, Catalog # PHG0154. Tested in Western Blot (WB), Immunohistochemistry (IHC), ELISA (ELISA), Control (Ctrl) and Functional Assay (Functional) applications. Supplied as 25 µg purified protein.

成纤维细胞生长因子 4： 该基因编码的蛋白质是成纤维细胞生长因子 (fgf) 家族的成员。 FGF 家族成员具有广泛的促有丝分裂和细胞存活活性，并参与多种生物过程，包括胚胎发育、细胞生长、形态发生、组织修复、肿瘤生长和侵袭。