2024年12月25日 · FGF16 (Fibroblast Growth Factor 16) is a Protein Coding gene. Diseases associated with FGF16 include Metacarpal 4-5 Fusion and Brachydactyly, Type A1 . Among its related pathways are Downstream signaling of activated FGFR2 and Apoptotic Pathways in Synovial Fibroblasts .

Fibroblast growth factor 16 is a protein which in humans is encoded by the FGF16 gene. [1][2] The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family.

fibroblast growth factor 16, metacarpal 4-5 fusion. Patient-specific iPSC-derived cardiomyocytes reveal abnormal regulation of FGF16 in a familial atrial septal defect. MiRNA-144-3p inhibits high glucose induced cell proliferation through suppressing FGF16. FGF16 is capable of inducing proliferation of iPSC-derived cardiac progenitor cells.

2016年2月24日 · 该研究利用心脏特异性基因敲除和基因过表达技术，揭示了转录因子gata4通过调节一个在心脏中特异表达的分泌型因子fgf16，来维持心脏的修复能力，并对损伤后引起的心肌肥厚起到一定的抑制作用。

2024年11月1日 · FGF16 has a broad expression pattern, predominantly expressed in brown adipose tissue, heart, with low but detectable levels in the brain, olfactory bulb, inner ear, muscle, thymus, pancreas, spleen, stomach, small intestine, and gonads (testis and ovary). FGF16 is also expressed moderately in the late developing limb bud.

该基因编码的蛋白质家族成员参与多种生物过程，包括胚胎发育、细胞生长、形态发生、组织修复、肿瘤生长和侵袭。 该基因在心脏细胞中表达，是心脏正常发育所必需的。 在具有掌骨 4-5 融合的个体中也观察到该基因的突变。 [RefSeq 提供，2014 年 3 月] This gene encodes a member of a family of proteins that are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.

2025年1月4日 · FGF16 enhanced cell migration in response to mechanical damage & failed to induce endothelial cell proliferation or sprouting in a three-dimensional in vitro angiogenesis assay. Title: Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation.

FGF16 has a broad expression pattern, predominantly expressed in brown adipose tissue, heart, with low but detectable levels in the brain, olfactory bulb, inner ear, muscle, thymus, pancreas, spleen, stomach, small intestine, and gonads (testis and ovary). FGF16 is also expressed moderately in the late developing limb bud.

2024年7月17日 · 成纤维细胞生长因子16（FGF16）属于FGF9亚家族成员，在胚胎发育、细胞增殖和细胞分化的调节中起重要作用，是正常心肌细胞增殖和心脏发育所必需的。 （数据来源AlphaFold） FGF16由207个氨基酸组成，属于分泌型胞外蛋白，无常规信号肽，主功能域为1-207区段，其中包括一处N型糖基化及一处磷酸化修饰。 （数据来源Uniprot） FGF16在物种间的保守性很高，序列差异很小。 除了早期关于FGF16在卵巢癌、肝细胞癌上报道的促进细胞侵袭 …

2022年11月18日 · Conjoint analysis of methylated RNA immunoprecipitation sequencing (MeRIP-seq) and RNA-seq identified Fgf16 as a downstream target of Mettl3-mediated m 6 A modification during postnatal heart regeneration. RIP-qPCR and luciferase reporter assays revealed that Mettl3 negatively regulates Fgf16 mRNA expression in an m 6 A-Ythdf2