The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of proteins. Some of these receptors are involved in pathological conditions. For example, a point …

2024年2月29日 · In this Review, we describe the development and current clinical role of FGFR inhibitors and provide perspective on future research directions including expansion of the therapeutic indications for...

2019年6月18日 · Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases expressed on the cell membrane that play crucial roles in both developmental and adult cells. Dysregulation of FGFRs has been implicated in a wide variety of cancers, such as urothelial carcinoma, hepatocellular carcinoma, ovarian cancer and lung adenocarcinoma.

2024年12月25日 · FGFR3 (Fibroblast Growth Factor Receptor 3) is a Protein Coding gene. Diseases associated with FGFR3 include Achondroplasia and Hypochondroplasia. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

2020年9月2日 · In this review, we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of diseases, which is a consequence of FGF signaling dysregulation, including cancers and chronic kidney disease (CKD).

2022年8月10日 · Somatic hotspot mutations and structural amplifications and fusions that affect fibroblast growth factor receptor 2 (encoded by FGFR2) occur in multiple types of cancer 1.

2021年4月1日 · Frequent tumor fibroblast growth factor receptor (FGFR) alterations are seen in many cancers, and include genetic amplifications, mutations, rearrangements and fusions. FGFR inhibitors target these receptor alterations and show promise as a drug class. Currently 2 medications are currently FDA approved: erdafitinib and pemigatinib.

The FGF‐FGFR signalling plays pivotal roles in the oncogenic process, and FGF/FGFR inhibitors are a promising method to treat FGFR‐altered tumours. The VEGF‐VEGFR signalling is the most crucial pathway to induce angiogenesis, and inhibiting this cascade has already got success in treating tumours.

Fibroblast growth factor receptor (FGFR) belongs to the super-family of receptor tyrosine kinases and is encoded by four genes (FGFR1, FGFR2, FGFR3, and FGFR4).

2019年6月6日 · 维普资讯中华医学遗传学杂志2004年12月第21卷第6期Chin J Med Genet，December 2004，Vo1．21，No．6 Fgfrg基因3 74点突变致软骨发育不全 小鼠模型的建立与分析 王建民 杜晓兰 李翠玲 尹良军 陈波 孙晶 苏楠 赵玲 宋瑞华 宋维威 陈林 邓初夏 【摘要】 目的 建立模拟人成纤维细胞生长因子3型受体（fibroblast growth ...