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2024年12月25日 · FGG (Fibrinogen Gamma Chain) is a Protein Coding gene. Diseases associated with FGG include Afibrinogenemia, Congenital and Dysfibrinogenemia, Congenital. Among its related pathways are Signaling downstream of RAS mutants and Toll Like Receptor 7/8 (TLR7/8) Cascade.

Fibrinogen gamma chain, also known as fibrinogen gamma gene (FGG), is a human gene found on chromosome 3. [5] The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains.

2012年2月1日 · The FGG gene provides instructions for making the fibrinogen gamma (γ) chain, one piece (subunit) of the fibrinogen protein. This protein is important for blood clot formation (coagulation), which is needed to stop excessive bleeding after injury.

Congenital fibrinogen deficiencies are rare bleeding disorders, characterized by extensive genetic heterogeneity in all the three genes: FGA, FGB, and FGG (enconding the Aα, Bβ, and γ chain, respectively).

Congenital fibrinogen disorders are caused by genetic variants occurring within all three fibrinogen genes. However, each gene (FGA, FGB, FGG) differently shows specific variants. Indeed, “nonsense” variants are mostly found within FGA, while FGG variants are prevalently responsible for missense changes. During the past years, knowledge of ...

The Aα, Bβ and γ polypeptide chains of fibrinogen are encoded by a three gene cluster on human chromosome four. The fibrinogen genes (FGB-FGA-FGG) are expressed almost exclusively in hepatocytes where their output is coordinated to ensure a sufficient mRNA pool for each chain and maintain an abundan …

FGA基因包括六个外显子，跨度为7. 5kb，位于FGG（10外显子，8. 5kb）和FGB（8外显子，8kb）之间，FGB基因是从相反方向转录的。 在不同的应激刺激（例如炎症和组织损害）下，三个人纤维蛋白原基因的协同转录被上调2～10倍。

2005年12月15日 · We investigated the association between haplotypes of fibrinogen alpha (FGA), beta (FGB), and gamma (FGG), total fibrinogen levels, fibrinogen γ′ (γA/γ′ plus γ′/γ′) levels, and risk for deep venous thrombosis.

Gene ID: 2266, updated on 8-Feb-2025. The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots.