Cell free hemoglobin impairs vascular function and blood flow in adult cardiovascular disease. In this study, we investigated the hypothesis that free fetal hemoglobin (fHbF) compromises vascular integrity and function in the fetoplacental circulation, contributing to the increased vascular resistance associated with fetal growth restriction (FGR).

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2024年8月1日 · 生物富集系数 （BCF, Bioconcentration Factor）: BCF 表示生物组织中某种化合物的浓度与同一时期该化合物在周围介质中的浓度之比。 它主要用于描述水生生物直接从周围水环境吸收污染物的能力，反映了污染物从水相转移到生物体内的过程，受污染物的物理化学性质（如溶解度、脂溶性）和生物体的生理特征影响。 【HJ837-2017中BCF的定义：因暴露（不含摄食）导致生物体内污染物质累积的浓度与所在水体中该污染物质浓度达到平衡时的比值，单位L/kg。 …

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Fetal hemoglobin (HbF) is a principal oxygen carrier in the blood of preterm and term neonates. Compared to adult hemoglobin, it has a significantly higher affinity for oxygen and its oxyhemoglobin dissociation curve (ODC) is left-shifted accordingly.

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Five studies showed that an increase in HbF changes the relation of partial oxygen pressure (paO2) to SpO2, which is physiologically explained by the leftward shift in oxygen dissociation curve. It is important to be aware of this shift when treating a neonate, especially for the lower SpO2 limits in preterm neonates to avoid undetected hypoxia.

2022年6月18日 · Fetal hemoglobin is the principal hemoglobin in the human fetus, and the adult levels of fetal hemoglobin (HbF) are less than 1% of total hemoglobin. A steady increase of HbF in patients with hereditary persistence of fetal hemoglobin (HPFH) is associated with complications.

In key studies we found that cells from mice with major deletions of the E-protein transcription factors, E2A and HEB, display greatly reduced RORγt/IL-17 expression and that E-protein-deficient mice exhibit greatly diminished IL-17-dependent inflammation in EAE models.

Hereditary persistence of fetal hemoglobin (HPFH) is a benign condition in which significant fetal hemoglobin production continues well into adulthood, disregarding the normal shutoff point after which only adult-type hemoglobin should be produced.