Filamins are a class of proteins that hold two actin filaments at large angles. [1] . Filamin protein in mammals is made up of an actin-binding domain at its N-terminus that is followed by 24 immunoglobulin-like repeat modules of roughly 95 amino acids. There are two hinge regions; between repeats 15-16 and 23-24.

2024年12月25日 · The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration.

2021年6月5日 · Filamin A (FLNa) is an actin-binding protein, which participates in the formation of the cytoskeleton, anchors a variety of proteins in the cytoskeleton and regulates cell adhesion and migration. It is involved in signal transduction, cell proliferation and differentiation, pseudopodia formation, ves …

该基因编码的蛋白质是一种肌动蛋白结合蛋白，可交联肌动蛋白丝并将肌动蛋白丝连接到膜糖蛋白上。 编码的蛋白质参与重塑细胞骨架以影响细胞形状和迁移的变化。 这种蛋白质与整合素、跨膜受体复合物和第二信使相互作用。 该基因的缺陷是多种综合征的原因，包括脑室周围结节性异位症 (PVNH1、PVNH4) 、耳腭指综合征 (OPD1、OPD2) 、额骨发育不良 (FMD) 、Melnick-Needles 综合征 (MNS) 和 X 连锁先天性特发性肠炎假性梗阻 (CIIPX) 。 已为该基因发现编码不同亚型的 …

Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes. They integrate cellular architectural and signalling functions...

Filamins are essential, evolutionary conserved, modular, multi-domain, actin-binding proteins that organize the actin cytoskeleton and maintain extracellular matrix connections by anchoring actin filaments to transmembrane receptors.

细丝蛋白A（filamin A，FLNa）是在非肌性细胞中发现的第一个肌动蛋白交联蛋白。 其可与90多种配体结合，包括通路蛋白、细胞内信号分子及转录因子等，具有整合细胞力学和信号转导的作用。

2010年1月11日 · Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin filament networks and link them to cellular membranes where they integrate cell architectural and signaling functions important for cell locomotion.

Filamins are large, dimeric proteins composed of an N-terminal ABD and multiple C-terminal immunoglobulin-like filamin (IgFLN) repeats arranged into two rods separated by flexible hinges. From: Progress in Molecular Biology and Translational Science, 2014

Filamin is a member of focal adhesion protein machinery that also plays a key role in regulating and bundling the acting filament network. A brief review is presented here on filamin and its important protein partners with the aim to shed light on the role of filamin's protein-protein interaction network in cell mechanobiology.