Catch-bond mechanism of the bacterial adhesin FimH - Nature
Mar 7, 2016 · We reveal a three-state mechanism of FimH catch-bond formation based on crystal structures of all states, kinetic analysis of ligand interaction and molecular dynamics simulations.
FimH and Anti-Adhesive Therapeutics: A Disarming Strategy Against ...
Jul 10, 2020 · The best-characterized bacterial adhesin is FimH, produced by uropathogenic Escherichia coli (UPEC). Hence, a number of high-affinity mono- and polyvalent mannose …
Bacterial adhesin - Wikipedia
FimH is a bacterial adhesin that helps bacteria such as Escherichia coli to bind to host cells and their receptors (here: the human proteins CD48 and TLR4, or mannose residues). [4] Most …
Rational Design Strategies for FimH Antagonists: New Drugs …
Recent efforts have culminated in the development of small-molecule mannoside FimH antagonists that target the mannose-binding lectin domain of FimH, inhibiting its function and …
Type 1 Fimbrial Adhesin FimH Elicits an Immune Response That …
The fimbrial tip-positioned adhesive protein FimH utilizes a shear force-enhanced, so-called catch-bond mechanism of interaction with its receptor, mannose, where the lectin domain of …
Escherichia coli adhesion portion FimH functions as an …
Mar 4, 2020 · In this study, we find that FimH, which is an Escherichia coli adhesion portion, induces toll-like receptor 4-dependent and myeloid differentiation protein 2-independent DC …
FimH confers mannose-targeting ability to Bacillus Calmette
rBCG-S.FimH is a novel BCG strain with significantly improved efficacy against bladder cancer. Since intravesical BCG immunotherapy is the first-line treatment for NMIBC, which accounts …
Structure-based design of an immunogenic, conformationally …
Feb 19, 2025 · FimH is an adhesin positioned on the fimbrial tip which binds to mannosylated proteins on the urinary tract epithelium via its lectin domain (FimH LD). FimH is of interest as a …
Positively selected FimH residues enhance virulence during urinary ...
FimH, the type 1 adhesin, binds mannosylated glycoproteins on the surface of human and murine bladder cells, facilitating bacterial colonization, invasion, and formation of biofilm-like …
Structural and functional characterization of the FimH adhesin …
Dec 1, 2021 · FimH is the fimbrial adhesin that is at the tip of the organelle and is highly conserved genetically and antigenically among Enterobacteriaceae genera. Perhaps FimF and …