In this study, we analyzed mutational patterns in the fimH gene of 52 mucosa-associated E. coli strains isolated from IBD and non-IBD pediatric patients, in order to investigate microevolution of this genetic trait. FimH-positive strains were also phylogenetically typed and tested for their adhesive ability on Caco-2 cells.

Our results highlight a mechanism of AIEC virulence evolution that involves selection of amino acid mutations in the common bacterial traits, such as FimH protein, and leads to the development of chronic inflammatory bowel disease (IBD) in a genetically susceptible host.

2013年1月24日 · Our results highlight a mechanism of AIEC virulence evolution that involves selection of amino acid mutations in the common bacterial traits, such as FimH protein, and leads to the development of chronic inflammatory bowel disease (IBD) in a genetically susceptible host.

2020年11月19日 · Adherent-invasive Escherichia coli have been suggested to play a pivotal role within the pathophysiology of inflammatory bowel disease (IBD). Autoantibodies against distinct splicing variants of glycoprotein 2 (GP2), an intestinal receptor of the bacterial adhesin FimH, frequently occur in IBD patie …

2024年12月17日 · analyzed mutational patterns in the fimH gene of mucosa-associated E. coli strains isolated from IBD and non-IBD pediatric patients to investigate microevolution of this genetic trait; study found some FimH variants that seem to be more involved than others in evolution of inflammatory bowel disease pathogenesis

2020年4月18日 · Adherent-invasive Escherichia coli have been suggested to play a pivotal role within the pathophysiology of inflammatory bowel disease (IBD). Autoantibodies against distinct splicing variants of glycoprotein 2 (GP2), an intestinal receptor of the bacterial adhesin FimH, frequently occur in IBD patients.

2009年5月21日 · Multi-locus sequence typing (MLST), and fimH sequence analysis were performed to elucidate the phylogenetic relationships between E. coli strains isolated from IBD tissue. Methods Thirty-six E. coli isolated from IBD patients and healthy individuals were used.

他们回顾了学界对 炎症性肠病（IBD）发病机制在宿主遗传学、宿主免疫、微生物群和环境暴露之间相互作用的理解，并总结了目前几种 利用微生物群提高IBD治疗效果 的方法，比如： 近日，《Cell》刊发一篇关于 IBD （炎症性肠病） 新疗法的综述，再次聚焦知几未来研究院已多次讨论过的这位“老朋友”： 本文由知几未来研究院（微信公众号：zhijiDNA）原创2019年8月22日，来自哈佛、MIT和马萨诸塞州总医院等一众知名机构的研究者，在《细胞》杂志发表名为《IBD疗法新 …

Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, have become increasingly prevalent across all human generations. ... (FimH protein mediates adherence to host cell surfaces). The FimH gene refers to the DNA sequence that encodes the FimH protein, when discussing its expression, mutations, or genetic regulation ...

2023年11月21日 · The FimH treatment in CD11b + CD103-DCs remarkably increased DSS-induced upregulation of co-stimulatory and MHC molecules (Figures 5E, F). In addition, FimH treatment induced phosphorylation of ERK, JNK, and p38 in CD11b + CD103-DCs, indicating DC maturation signaling pathway activation .