Peptidyl-prolyl cis-trans isomerase FKBP1A is an enzyme that in humans is encoded by the FKBP1A gene. [5] It is also commonly referred to as FKBP-12 or FKBP12 and is a member of a family of FK506-binding proteins .

2024年12月25日 · FKBP1A (FKBP Prolyl Isomerase 1A) is a Protein Coding gene. Diseases associated with FKBP1A include Fibrodysplasia Ossificans Progressiva and Subependymal Glioma. Among its related pathways are TGF-beta receptor signaling activates SMADs and Infectious disease.

2023年9月16日 · Our findings revealed that FKBP1A exhibited aberrant upregulation in most human cancers, making it a potential biomarker for malignancy. Moreover, FKBP1A expression correlated with poor overall survival, disease-specific survival, disease-free interval, and progression-free interval in several cancers, indicating its prognostic significance.

Upregulated FKBP1A Suppresses Glioblastoma Cell Growth via Apoptosis Pathway. The Prognostic Significance of FKBP1A and Its Related Immune Infiltration in Liver Hepatocellular Carcinoma. FKBP1A upregulation correlates with poor prognosis and increased metastatic potential of HNSCC.

该蛋白质是一种顺反式脯氨酰异构酶，可结合免疫抑制剂 FK506 和雷帕霉素。 它与多种细胞内信号转导蛋白相互作用，包括 I 型 TGF-β 受体。 它还与多个细胞内钙释放通道相互作用，并协调四聚体骨骼肌兰尼碱受体的多蛋白复合物形成。 在小鼠中，该同源基因的缺失会导致先天性心脏病，称为左心室心肌致密化不全。 已经鉴定出编码相同蛋白质的多个可变剪接变体。 人类基因组包含五个与该基因相关的假基因，其中至少一个被转录。 [RefSeq 提供，2008 年 9 月]

2022年10月24日 · FKBP1A was first discovered as a receptor for the immunosuppressant drug FK506 in immune cells and is critical for various tumors and cancers. However, the relationships between FKBP1A expression, cellular distribution, tumor immunity, and prognosis in LIHC remain

2024年12月10日 · Title: FKBP1A upregulation correlates with poor prognosis and increased metastatic potential of HNSCC. FKBP51 promotes invasion and migration by increasing the autophagic degradation of TIMP3 in clear cell renal cell carcinoma.

We demonstrated that FKBP1A was the hub gene in GBM via a weighted correlation network analysis (WGCNA) and differentially expressed genes (DEGs) analysis based on the bulk RNA-seq data from TCGA and GTEx. Afterwards, we proved that the upregulated FKBP1A protein could promote GBM cell death by CCK-8 assays in U87MG and t98g GBM cell lines.

The encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, and is associated with immunoregulation, protein folding, receptor signaling, protein trafficking and T-cell activation. It may modulate the calcium release activity of the ryanodine receptor Ryr1.

2023年9月16日 · 本研究旨在全面探究FKBP1A在癌症中的多方面作用，特别是在肺癌中的作用，以期为肺癌的治疗和预后提供新的思路。 本研究使用了GTEx、TCGA、HPA和cBioPortal等大规模数据集，分析了FKBP1A在正常组织和各种癌症类型中的表达情况。 研究发现，FKBP1A在大多数人类癌症中表达异常上调，可能成为恶性肿瘤的潜在生物标志物。 此外，FKBP1A的表达与多种癌症的总体生存率、疾病特异性生存率、无病生存期和无进展生存期呈负相关，表明其在肿瘤 …