2020年1月1日 · Flavin-dependent enzymes utilize flavin derivatives derived from vitamin B2 or riboflavin as cofactors or co-substrates to catalyze their reactions. These enzymes can catalyze a wide range of catalytic reactions including redox and non-redox types.

Flavin-dependent enzymes catalyze a wide variety of biological reactions that are important for all types of living organisms. Knowledge gained from studying the chemistry and biological functions of flavins and flavin-dependent enzymes has continuously made significant contributions to …

2025年1月31日 · Two engineered flavin-dependent enzymes are successfully developed to catalyze stereoselective hydrotrifluoromethylation and trifluoromethyl-alkyl cross-electrophile coupling reactions using...

Volume 47: Flavin-Dependent Enzymes: Mechanisms, Structures and Applications Edited by Pimchai Chaiyen - School of Biomolecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Wangchan Valley, Rayong, Thailand

2010年3月1日 · A study of 374 flavin‐dependent proteins analyzed with regard to their function, structure and distribution among 22 archaeal, eubacterial, protozoan and eukaryotic genomes appears that some species depend heavily on flavIn‐dependent oxidoreductases for degradation or biosynthesis, whereas others have minimized their flavoprotein arsenal.

Flavoenzymes play a key role in metabolism, shuffling electrons between two-electron reactants (e.g., NADPH, fumarate, lactate) and one-electron reactants such as the metal centers and quinones of the respiratory chain.

2024年12月2日 · Nitroreductases, present within both prokaryotes and eukaryotes, form a group of flavin-dependent enzymes capable of reducing nitro compounds using NAD (P)H as reducing agent. These enzymes have been widely studied due to their diverse roles in bioremediation, cancer therapy, cell ablation, and antimicrobial resistance.

In this review, we focus on flavin-dependent N-hydroxylating enzymes, which play a major role in the production of secondary metabolites, such as siderophores or antimicrobial agents. Flavoprotein monooxygenases of higher organisms (among others, in humans) can interact with nitrogen-bearing secondary metabolites or are relevant with respect to ...

2018年1月11日 · Two-component flavin-dependent enzymes require two separate proteins to carry out the overall reaction; an NAD(P)H-dependent reductase delivers reduced FMN or FAD to the monooxygenase component, where the reaction with molecular oxygen and an organic substrate takes place.

Flavin-dependent monooxygenases are enzymes that display a remarkable versatility in their cellular functions. Here, we have demonstrated that a subset of these enzymes (classes A, B, E, F, and G) shares a common origin and that a complex set of events has taken place during their evolutionary history to result in the differences between them.