2001年11月27日 · The loss of Thy-1.1 and gain of Flk-2 expression marks the loss of self-renewal in HSC maturation. The addition of Flk-2 antibody to the lineage mix allows direct isolation of LT-HSC from adult bone marrow as c-kit + lin − Sca-1 + Flk-2 − from many strains of mice. Fetal liver HSCs are contained within Flk-2 − and Flk-2 + KTLS cells.

CD135，又称FLK-2、FLT3和Ly-72，是一种III型酪氨酸激酶受体。 CD135既表达在正常的CD34+造血干细胞中，也表达于恶性造血细胞，包括AML、ALL和CML BC。

为了确定Flk-2 / Flt3受体酪氨酸激酶是否在最原始的LT-HSC上表达，我们根据Flk-2表面表达对高度纯化的多能干细胞和祖细胞进行了分类，并将其用于竞争性重组分析。

1994年10月15日 · The flk-2/flt-3 receptor tyrosine kinase was cloned from a hematopoietic stem cell population and is considered to play a potential role in the developmental fate of the stem cell. Using antibodies derived against the extracellular domain of the receptor, we show that stem cells from both murine fetal liver and bone marrow can express flk-2/flt-3.

The novel hematopoietic growth factor FLT3 ligand (FL) is the cognate ligand for the FLT3, tyrosine kinase receptor (R), also referred to as FLK-2 and STK-1. The FLT3R belongs to a family of receptor tyrosine kinases involved in hematopoiesis that also includes KIT, the …

We investigated the effect of Flk2 deficiency on myelopoiesis, focusing on specification of progenitors between HSC and mature cells. We provide evidence that Flk2 is critical for proliferative expansion of multipotent progenitors that are common precursors for all lymphoid and myeloid lineages, including megakaryocyte/erythroid (MegE) cells.

2008年6月15日 · We analyzed the developmental potential of CLP F and CLP F− and demonstrated that while the Flk2 − subfraction of CLP contain only B-restricted progenitors, Flk2 + CLP possess robust T-cell, B-cell, NK, and DC potential, and completely lack myeloid potential.

1994年10月15日 · The flk-2/flt-3 receptor tyrosine kinase was cloned from a hematopoietic stem cell population and is considered to play a potential role in the developmental fate of the stem cell. Using antibodies derived against the extracellular domain of the receptor, we show that stem cells from both murine fet …

2007年11月16日 · FLT3/FLK2, a member of the receptor tyrosine kinase family, plays a critical role in maintenance of hematopoietic homeostasis, and the constitutively active form of the FLT3 mutation is one of the most common genetic abnormalities in acute myelogenous leukemia.

Simultaneous analysis of Thy-1.1 and Flk-2 expression by a c-kit+ Lin-/l1 Sca-1+ fraction of WBM identified three distinct populations (Fig. 2A): Thy-1.110 Flk-2- (LT-HSC), Thy-1.110 Flk-2+ …