2024年5月7日 · Mechanistically, FLNA knockdown inhibited epithelial-mesenchymal transition (EMT) in PTC and affected the activation of the FAK/AKT signaling pathway. In addition, FLNA …

Filamin A (FLNa), as an actin‑binding protein, can interact with various signaling molecules and membrane receptors to affect cell signal transduction and function. However, whether FLNa is …

High FLNA expression was significantly associated with increased TNM stage, T stage, and N stage, as well as poor DFI and PFI in patients with PTC. Biological experiments demonstrated …

2021年2月10日 · Our gene chip array, quantitative polymerase chain reaction validation, and shRNA-based high-content screening identified the Akt kinase lanthionine synthetase C-like …

2020年2月1日 · Our results indicated HGF stimulation promoted phosphorylation of AKT and FLNA (ser2152), while blockage of AKT signaling by c-Met inhibitor Crizotinib or PI3K inhibitor …

2015年12月1日 · FLNa is a ubiquitous cytoskeletal protein that links transmembrane receptors, including integrins, to F-actin and functions as a signalling intermediate. We investigated …

FLNa functions as a cytoskeletal protein that links transmembrane receptors, including integrins, to F-actin and serves as a signaling inter-mediate. Recent studies have identified FLNa as a …

FLNa is a ubiquitous cytoskeletal protein that links transmembrane receptors, including integrins, to F-actin and functions as a signalling intermediate. We investigated FLNa's role in the …

Mechanistically, FLNA knockdown inhibited epithelial–mesenchymal transition (EMT) in PTC and affected the activation of the FAK/AKT signaling pathway. In addition, FLNA expression was …

2007年4月9日 · Transfection of FlnA16–24 cDNA in C4–2 cells restored expression and nuclear localization of 90 kDa FlnA. Unlike LNCaP, C4–2 cells proliferate in androgen-reduced …