2023年11月1日 · DRD2 plays a critical role in the FLNA-ERK signaling pathway. DRD2 gene is hypomethylated in hormone-receptor-negative breast cancer or it's high-risk factor. We …

体内和体外实验表明，Filamin A 和细胞外信号调节激酶 (FLNA-ERK) 的磷酸化受到 DRD2 表达的影响，表明 DRD2 在 FLNA-ERK 信号通路中发挥作用。 甲基化抑制剂（5-aza-2-脱氧胞 …

2021年6月5日 · Besides, FLNa overexpresses in docetaxel resistant triple-negative breast cancer (TNBC) and regulates drug sensitivity through the MAPK/ERK pathway (Zhao et al., 2016). If …

In vivo and in vitro experiments demonstrated the phosphorylation of filamin A and extracellular signal-regulated kinase (FLNA-ERK) was influenced by the expression of DRD2, suggesting …

裸鼠实验发现，过表达DRD2可促进肿瘤生长和Ki67、CD31表达，下调DRD2可抑制肿瘤生长。体内外实验表明，细胞外调节蛋白激酶（extracellular regulated protein kinases，ERK）的表达 …

2015年11月7日 · FLNA can function as a modulator of chemosensitivity to docetaxel in TNBC cells through regulation of the MAPK/ERK pathway both in vitro and in vivo. FLNA may serve …

2023年9月9日 · 通过体内外实验，研究人员证实了DRD2参与了乳腺癌的增殖和生长，并发现DRD2通过影响filamin A和ERK信号通路来调控乳腺癌的发生。 此外，研究人员还使用甲基化 …

Filamin A (FLNa), as an actin‑binding protein, can interact with various signaling molecules and membrane receptors to affect cell signal transduction and function. However, whether FLNa is …

2018年6月5日 · Here, we uncover the ERK activity dynamics in intestinal epithelial cells (IECs) and their association with tumour characteristics. Intravital imaging identifies two distinct …

FLNa knockdown promotes EGF-induced EGFR/Akt/ERK phosphorylation in SW480 cells. SW480 cells were transfected with shRNA FLNa or control shRNA for 24 h. Then cells were …