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The fluorenylmethoxycarbonyl protecting group (Fmoc) is a base-labile amine protecting group used in organic synthesis, particularly in peptide synthesis. [1] It is popular for its stability toward acids and hydrolysis and its selective removal by weak bases, such as piperidine , without affecting most other protecting groups or sensitive ...

What is the Fmoc Protecting Group? Fmoc is a fluorenylmethoxycarbonyl group that forms carbamates with amines. However, as a common theme, alcohols and other nucleophiles can also be protected. Fmoc was introduced by Carpino in 1972 [1]. You will realize that this is pretty late in the game!

Fluorenylmethyloxycarbonyl chloride (Fmoc-Cl) is a chloroformate ester. It is used to introduce the fluorenylmethyloxycarbonyl protecting group as the Fmoc carbamate.

Reagent for derivatizing amino acids for HPLC amino acid analysis and for preparing N-Fmoc amino acids for solid-phase peptide synthesis.

While the latter technology has continued to undergo further refinement and improvement in both its chemistry and automation, the development of the base-labile 9-fluorenylmethoxycarbonyl (Fmoc) group and its integration into current synthesis methods is considered a major landmark in the history of the chemical synthesis of peptides.

The development of the fluorenyl methoxycarbonyl protecting group (FMOC) and its move into organic synthesis methods represents a clear breakthrough in chemistry.

A simple and efficient protection procedure is general and regioselective for the preparation of mono-N-Boc, N-Cbz, N-Fmoc or N-Alloc aromatic amines in high yield without affecting aliphatic amino groups and other functionalities.

Protecting groups (PGs) in peptide synthesis have inspired advanced design principles that incorporate “orthogonality” for selective C- and N-terminus and side-chain deprotections. The conventionally acid-stable 9-fluorenylmethoxycarbonyl (Fmoc) ...

In Fmoc SPPS, this step is normally carried out by treating the peptidyl resin with TFA. During this process, highly reactive cationic species are generated from the protecting groups and the handles on the resin, and these can, unless trapped, react with, and hence modify, those residues which contain nucleophilic functional groups: Trp, Met ...