2011年6月5日 · The structure of an RNA quadruplex-duplex junction in complex with an Arg-Gly-rich peptide from Fragile X mental retardation protein (FMRP) now reveals an unprecedented RNA scaffold and...

2025年3月18日 · Here, we examined RNA sequences with increasing G content and G4 propensity in complex with the RGG-containing low complexity region (LCR) of FMRP.

Our analysis has identified FMRP, FUS, and G3BP1 as three well-known RBPs in which an rG4/RGG pair connected by coding overlaps with the known binding sites as identified by eCLIP (Fig. 6).

2010年4月1日 · FMRP is methylated on the high-affinity RNA-binding motif, the RGG box, at positions 533, 538, 543 and 545 of murine FMRP. To identify the arginines important for FMRP function, we examined their role in polyribosome and mRNA association.

2018年11月2日 · A large-scale microarray study of FMRP-interacting mRNAs indicated that two-thirds of them contain sequences capable of forming G-quadruplexes, substantiating G-quadruplexes as a target for RGG/RG motifs [32].

FMRP uses an arginine-glycine-rich (RGG) motif for specific interactions with guanine (G)-quadruplexes, mRNA elements implicated in the disease-associated regulation of specific mRNAs. Here we report the 2.8-Å crystal structure of the complex between the human FMRP RGG peptide bound to the in vitro selected G-rich RNA.

2015年9月29日 · FMRP uses an arginine-glycine-rich (RGG) motif for specific interactions with guanine (G)-quadruplexes, mRNA elements implicated in the disease-associated regulation of specific mRNAs. Here we report the 2.8-Å crystal structure of the complex between the human FMRP RGG peptide bound to the in vitro selected G-rich RNA.

2011年6月5日 · We have determined the solution structure of the complex between an arginine-glycine-rich RGG peptide from the human fragile X mental retardation protein (FMRP) and an in vitro-selected guanine-rich (G-rich) sc1 RNA. The bound RNA forms a newly discovered G-quadruplex separated from the flanking dup …

2015年9月9日 · FMRP uses an arginine-glycine-rich (RGG) motif for specific interactions with guanine (G)-quadruplexes, mRNA elements implicated in the disease-associated regulation of specific mRNAs. Here we report the 2.8-Å crystal structure of the complex between the human FMRP RGG peptide bound to the in vitro selected G-rich RNA.

2011年4月1日 · We have determined the solution structure of the complex between an arginine-glycine-rich RGG peptide from the human fragile X mental retardation protein (FMRP) and an in vitro–selected guanine-rich (G-rich) sc1 RNA. The bound RNA forms a newly discovered G-quadruplex separated from the flanking duplex stem by a mixed junctional tetrad.