Focal adhesion - Wikipedia
In cell biology, focal adhesions (also cell–matrix adhesions or FAs) are large macromolecular assemblies through which mechanical force and regulatory signals are transmitted between the extracellular matrix (ECM) and an interacting cell.
Focal adhesion焦点粘附FAs-武汉华美生物
焦点粘附（Focal adhesion）是细胞与外部基质之间的一个重要连接点，它由多个蛋白质组成，包括整合素、钙蛋白、肌动蛋白等。 焦点粘附的形成和稳定对于细胞凋亡、增殖、迁移、分化等过程都具有重要作用。
Structure and function of focal adhesions - PubMed
By responding to chemical and mechanical cues several allosterically regulated proteins create a dynamic multifunctional protein network that provides both adhesion to the extracellular matrix as well as intracellular signaling in response to mechanical changes in the cellular environment.
Focal adhesion - Homo sapiens (human) - KEGG
At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins.
Focal Adhesion: A Focal Point in Current Cell Biology and …
One of the earliest and perhaps best-characterized cell-ECM adhesion structures is focal adhesion, which represents strong ECM adhesion structures that are often found in adherent cells (e.g., fibroblasts) cultured on rigid ECM substrata.
Structure and function of focal adhesions - ScienceDirect
2012年2月1日 · The study of focal adhesion formation and assembly requires bringing integrin-receptor expressing cells in contact with extracellular matrix. As focal adhesions form in protrusive parts of cells, such as filopodia and lamellipodia, these cellular structures also possess the critical elements to assemble integrin-dependent adhesions.
Focal Adhesions - SpringerLink
Strength of cell adhesion can be achieved by grouping individual integrins in clusters, the so‐called focal adhesions. The formation of focal adhesions involves several steps, including integrin activation and recruitment of cytoskeletal adaptor proteins ( 1 ).
Focal adhesion | Nature Cell Biology
2021年8月8日 · Focal adhesions are large structures through which integrins and scaffold proteins link the actin cytoskeleton to the extracellular matrix.
Focal adhesions, reticular adhesions, flat clathrin lattices: What ...
5 天之前 · The best studied ones are the focal adhesions in which integrins become firmly linked to contractile actomyosin fibers allowing for force transduction. But integrins also form an integral part of adhesion structures that lack the strong actomyosin link and are enriched in endocytic proteins. These have been named reticular adhesions, flat ...
Focal adhesions: Current Biology - Cell Press
1999年6月17日 · Focal adhesions are the anchor points of the cell. These dynamic cytoskeletal structures are regions where the cell membrane firmly attaches to the extracellular matrix or the substratum. At the same time, focal adhesions provide scaffolding; they associate with an elaborate actin network inside the cell.
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