Focal adhesion - Wikipedia
Focal adhesions are integrin-containing, multi-protein structures that form mechanical links between intracellular actin bundles and the extracellular substrate in many cell types. Focal adhesions are large, dynamic protein complexes through which the cytoskeleton of a cell connects to the ECM.
Integrin adhesion complexes: Current Biology - Cell Press
2021年5月24日 · For example, the fibronectin-binding integrins α5β1 and αvβ3 show differential regulation of focal adhesions; α5β1 integrin promotes adhesion turnover and is enriched in nascent adhesions, while αvβ3 integrin stabilises adhesions and is …
Focal adhesion kinase and its role in skeletal muscle - PMC
This review will focus on the role of focal adhesion kinase (FAK), a prominent and well-studied protein that responds to changes in cellular tension. FAK is a 125 kDa non-receptor tyrosine kinase that lies within and coordinates signals through a multiprotein complex called the focal adhesion complex (Schaller et al. 1995).
Structure and function of focal adhesions - PubMed
Specifically, it is critical to understand how small differences in binding of integrins to extracellular ligands and/or cytoplasmic adapter proteins affect the assembly and function of an entire focal adhesion.
Focal Adhesion: A Focal Point in Current Cell Biology and ...
One of the earliest and perhaps best-characterized cell-ECM adhesion structures is focal adhesion, which represents strong ECM adhesion structures that are often found in adherent cells (e.g., fibroblasts) cultured on rigid ECM substrata.
Focal Adhesions: a personal perspective on a half century of ...
Focal adhesions are specialized sites within the cell where clustered integrin receptors interact with the extracellular matrix on the outside of cells and with the actin cytoskeleton on the inside.
Structure and function of focal adhesions - ScienceDirect
2012年2月1日 · In focal adhesions, specific plasma membrane lipids, as well as mechanical tension induce conformational changes to focal adhesion proteins creating a mechanosensing and signal transducing protein network.