In chemistry, a foldamer is a discrete chain molecule (oligomer) that folds into a conformationally ordered state in solution. They are artificial molecules that mimic the ability of proteins, nucleic acids, and polysaccharides to fold into well-defined conformations, such as …

2007年4月16日 · Foldamers are sequence-specific oligomers akin to peptides, proteins and oligonucleotides that fold into well-defined three-dimensional structures. They offer the chemical...

2001年12月12日 · Redox-Regulated and Guest-Driven Transformations of Aromatic Oligoamide Foldamers in Advanced Structures. Journal of the American Chemical Society 2024, 146 (19) , 12907-12912. https://doi.org/10.1021/jacs.4c03275

f synthetic foldamers. The path to creating useful foldamers involves . everal daunting steps. (i) One must identify new polymeric backbones with suitabl. folding propensities. This goal includes developing a predictively useful understanding of the relationship between the repetitive features of monomer structure and conformational propertie.

Foldamers are artificial folded molecular architectures inspired by the structures and functions of biopolymers. This highlight focuses on important developments concerning foldamers produced by chemical synthesis and on the perspectives that these new self …

2020年9月16日 · It covers topics ranging from foldamer design (new foldamers and their building blocks), applications (for example biology and medicinal chemistry), foldamers for bio- and nanomaterials, and catalysis.

2020年7月18日 · Regardless of the backbone type (peptidic or abiotic), the most important features of foldamers are the high stability, easy predictability and tunability of their folding, as well as the possibility to endow them with enhanced biological functions, with respect to their natural counterparts, by the correct choice of monomers.

2017年6月29日 · Bio-inspired synthetic backbones leading to foldamers can provide effective biopolymer mimics with new and improved properties in a physiological environment, and in turn could serve as useful tools to study biology and lead to practical applications in the areas of diagnostics or therapeutics.

Over the past decade, foldamers have progressively emerged as useful architectures to mimic secondary structures of proteins. Peptidic foldamers, consisting of various amino acid based backbones, have been the most studied from a therapeutic perspective, while polyaromatic foldamers have barely evolved from their nascency and remain perplexing ...

2020年1月1日 · Foldamers are non-natural oligomers that mimic the structural behaviour of natural peptides, proteins and nucleotides by folding into a well-defined 3D conformation in solution.