Tumor protein p63, typically referred to as p63, also known as transformation-related protein 63, is a protein that in humans is encoded by the TP63 (also known as the p63) gene. [5][6][7][8]

2021年1月25日 · Tumor protein 63 (p63) is a transcription factor of the p53 gene family encoded by the TP63 gene located at chromosome 3q28. p63 regulates the activity of a multitude of genes involved in growth and development of the ectoderm and derived structures and tissues, such as basal layer keratins and cell cycle control genes [1].

采用免疫组织化学法检测p63、34βE12和S-100在不同前列腺病变组织中的表达 情况,探讨其对前列腺癌的诊断价值。 结果:p63在58例前列腺癌组中无弱阳性、阳性表达,58例(100.00%)阴

2024年12月25日 · TP63 (Tumor Protein P63) is a Protein Coding gene. Diseases associated with TP63 include Adult Syndrome and Limb-Mammary Syndrome. Among its related pathways are TP53 Regulates Transcription of Cell Death Genes and Gene expression (Transcription).

1 天前 · Immunohistochemistry demonstrated a strong nuclear expression of p63 in the basal cells of the hyperplastic glands. These features correlate with benign prostatic hyperplasia. Which of the statements below regarding p63 is true? B. Loss of p63 expression correlates with poor prognosis in urothelial carcinoma.

2023年11月27日 · p63是位于染色体3q28上的 TP63基因 编码、 p53基因家族 的 转录因子。 该蛋白调节与外胚层及其衍生组织生长、发育相关基因的活性，并通过其复杂的异构体来促进肿瘤发生。 正常情况下，p63表达于 鳞状上皮 、 尿路上皮 、细胞滋养细胞、多种器官的基底层细胞（也包括乳腺腺上皮系统的 肌上皮细胞 层）。 病理状态下，p63一般表达于p63阳性正常组织来源的病变，且p63阴性组织来源的病变中一般检测不到，但的确有例外的情况。 有报道称，p63阴性组 …

2021年1月15日 · p40 是 p63 蛋白的亚型之一，阳性定位在细胞核。 其被认为是特异性和敏感性最高的鳞癌标志物。 与 P63 相比，P40 在肺鳞癌中的敏感性与 P63 相当，而在肺腺癌和淋巴瘤中几乎不表达，故而特异性也很高。

The TP63 gene provides instructions for making a protein called tumor protein p63 (also known simply as p63). The p63 protein functions as a transcription factor, which means it attaches (binds) to certain regions of DNA and controls the activity of particular genes.

2012年12月1日 · TP63 binds DNA as either a homo- or a heterotetramer, with isoform composition of the tetramer possibly determining transactivation activity. p63 may also form mixed dimers or tetramers with p73 at relatively higher affinity than with p53, suggesting functional cross talk to regulate transcriptional activity (Davison et al., 1999; Natan and ...

2022年3月21日 · Sequence analysis and structure determination have revealed a high similarity of crucial domains between p53, p63 and p73. Functional studies, however, have shown a wide variety of different...