Forkhead box protein M1 is a protein that in humans is encoded by the FOXM1 gene. [5][6] The protein encoded by this gene is a member of the FOX family of transcription factors. [5][7] Its potential as a target for future cancer treatments led to …

2025年1月15日 · FOXM1 is transcriptionally super-active towards oncogenic targets in a phase-separated state, and we revealed a mechanism for the role of FOXM1 LLPS-mediated FKH-DNA binding. We identified...

Oncogenic FOXM1 underwent liquid-liquid phase separation (LLPS) with FKH consensus DNA element, and compartmentalized the transcription apparatus in the nucleus, thereby sustaining chromatin accessibility and superenhancer landscapes crucial for tumour metastatic outgrowth.

FOXM1 (Forkhead box protein M1) [1] 是一种 转录因子 蛋白质，有关调节 细胞周期 的重要作用。 当FOXM1从小鼠中去除后，幼鼠在出生后不久因心臟衰竭而死亡，由于心肌细胞和肝细胞 多倍体 的发展 [2]。 研究显示了FOXM1对 染色体 偏析 和 基因组 稳定性有重大作用。 FOXM1因子失调表达了会造成异常的细胞增殖，导致引发癌症 [3][4][5][6][7][8][9]。 分子 细胞生物学及生物技术方案暨研究国际协会 (简称为ISMCBBPR)已将FOXM1评为2010年的年度之重要分子。 …

2024年12月25日 · FOXM1 (Forkhead Box M1) is a Protein Coding gene. Diseases associated with FOXM1 include Hepatocellular Carcinoma and Alagille Syndrome 1. Among its related pathways are Signaling by ALK fusions and activated point mutants and Loss of proteins required for interphase microtubule organization from the centrosome.

foxm1是一种已知的 原癌基因 ，与细胞增殖、细胞周期、细胞分化、dna损伤修复、组织稳态、凋亡和氧化还原信号转导有关，foxm1有促进组织再生的潜能，鉴于其促癌性已得到充分的研究，有必要在长期的研究中详细评估其潜在的致癌副作用，识别受影响的细胞 ...

foxm1在超过20种人类肿瘤中过表达，促进肿瘤细胞的增殖、侵袭、转移、抗凋亡和化 疗耐药等过程。 越来越多的证据表明，FOXM1在肿瘤细胞增殖与代谢之间发挥信使作用，使肿瘤细胞的增殖与代谢相适应。

FOXM1 maintains cancer hallmarks by regulating the expression of target genes at the transcriptional level. Due to its potential role as molecular target in cancer therapy, FOXM1 was named the Molecule of the Year in 2010. However, the mechanism of FOXM1 dysregulation remains indistinct.

2021年6月19日 · As a master transcriptional regulator, FOXM1 promotes critical oncogenic phenotypes in ovarian cancer, including: (1) cell proliferation, (2) invasion and metastasis, (3) chemotherapy resistance, (4) cancer stem cell (CSC) properties, (5) genomic instability, and (6) altered cellular metabolism.

1月15日，我校生物医学研究院周芳芳教授团队在《自然》（Nature）在线发表题为“Targeting FOXM1 condensates reduces breast tumour growth and metastasis”的合作研究论文，阐述了靶向凝聚体以提升肿瘤免疫原性的方法。...