2021年6月21日 · FOXM1 IHC results were evaluated and graded based on unclear staining intensity by pathologists. Selected images represent IHC staining scores, classified as 0, 1+, 2+, and 3+.

We explored the expression profiles and the prognostic value of FOXM1 in pan-cancer across The Cancer Genome Atlas (TCGA). We further used lung adenocarcinoma (LUAD) tissues combined with quantitative real-time PCR (qRT-PCR) and immunohistochemistry (IHC) for experimental validation of FOXM1 expression.

2021年6月11日 · For immunohistochemical (IHC) study of DKK1 and FOXM1 expression, tumors in which positive staining covered 5–20% of the total area were classified as DKK1- or FOXM1- low expression, and...

2018年2月13日 · The expression level of FOXM1 in 78 pairs of ESCC cancerous and para-cancerous tissue samples was analyzed by RT-qPCR, western blotting and IHC. The expression level of FOXM1 mRNA was significantly increased in ESCC tissues compared with in normal paired tissues (Fig. 1A; P<0.01).

IHC staining was used to detect the expression levels of FoxM1 protein in 113 NPC tissues and 29 non-cancerous nasopharyngeal samples. FoxM1 was found to be localized in the nucleus and cytoplasm of primary cancer cells.

2021年2月1日 · Our findings suggest that a general FoxM1-STMN1 axis contributes to cell proliferation and tumorigenesis in hepatocellular carcinoma, gastric cancer and colorectal cancer. The combination of...

2017年8月9日 · FoxM1 is highly expressed in HSCC and is associated with tumor progression. To evaluate the expression of FoxM1 in HSCC, IHC was used to examine FoxM1 expression in 63 HSCC specimens at different levels of malignancy and 20 adjacent normal tissue specimens.

2023年4月29日 · IHC assay displayed that a number of infiltrated neutrophils in the tumor microenvironment were positively associated with the expression of FOXM1 in EC (Figure 5(e)). Taken together, FOXM1 may contribute to regulating the tumor immune microenvironment through neutrophil infiltration in EC.

FOXM1 knockdown significantly reduced the expression of GLUT1 among key glycolysis-related molecules in the different HCC cell lines. Glucose uptake and lactate production assay showed that FOXM1 positively regulated glycolysis based on GLUT1 expression. Moreover, FOXM1 overexpression increased and knockdown decreased GLUT1 expression.

2018年10月1日 · IHC staining has also revealed that the level of FoxM1 expression remains significantly higher in gastric cancer than in adjacent non-cancerous tissues. Microarray analysis and RT-PCR have enabled identification of FoxM1 as a candidate gene whose differential expression leads to glioma progression.