Novel FOXM1 inhibitor identified via gene network analysis …
2021年7月14日 · We performed a network-centric transcriptomic analysis to identify a novel compound STL427944 that selectively suppresses FOXM1 by inducing the relocalization of …
Novel FOXM1 inhibitor STL001 sensitizes human cancers to a …
2024年5月2日 · The novel FOXM1 inhibitor STL001, developed by the first-generation modification in its parental compound STL427944, is more efficient in reducing the cellular …
FOXM1 affects oxidative stress, mitochondrial function, and the …
2024年11月1日 · Moreover, FOXM1 inhibition significantly increased the protein expression levels of dynamin-related protein 1 (DRP1) and decreased the protein expression levels of mitofusin …
FOXM1 nuclear transcription factor translocates into mitochondria …
2020年6月15日 · Forkhead box M1 (FOXM1), a nuclear transcription factor that activates cell cycle regulatory genes, is highly expressed in a majority of human cancers. The function of …
ABL1-mediated phosphorylation promotes FOXM1-related
2024年7月26日 · Here, we show that ABL1, a nonreceptor tyrosine kinase, contributes to the high expression of FOXM1 and FOXM1-dependent tumor development. Mechanistically, ABL1 …
FOXM1: A key oncofoetal transcription factor in health and …
2014年12月1日 · Forkhead Box M1 (FOXM1) is a bona fide oncofoetal transcription factor, which orchestrates complex temporal and spatial gene expression throughout embryonic and foetal …
FOXM1: Functional Roles of FOXM1 in Non-Malignant Diseases
Early studies have shown that forkhead box M1 (FOXM1) functions as a key gene in pathological processes in multiple diseases by regulating genes related to proliferation, the cell cycle, …
FOXM1: A small fox that makes more tracks for cancer
2023年7月1日 · FOXM1 regulates the expression of different ABC transporters in various cancer types. In nasopharyngeal carcinoma, FOXM1 induces paclitaxel resistance by regulating the …
Regulation of the master regulator FOXM1 in cancer - PMC
FOXM1 maintains cancer hallmarks by regulating the expression of target genes at the transcriptional level. Due to its potential role as molecular target in cancer therapy, FOXM1 …
抗衰老研究的新靶点——FOXM1 - 知乎 - 知乎专栏
FOXM1是一种已知的 原癌基因，与细胞增殖、细胞周期、细胞分化、DNA损伤修复、组织稳态、凋亡和氧化还原信号转导有关，FOXM1有促进组织再生的潜能，鉴于其促癌性已得到充分的 …