Forkhead box protein N1 is a protein that in humans is encoded by the FOXN1 gene. [5][6] Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system.

2024年12月25日 · FOXN1 (Forkhead Box N1) is a Protein Coding gene. Diseases associated with FOXN1 include T-Cell Immunodeficiency, Congenital Alopecia, And Nail Dystrophy and T-Cell Lymphopenia, Infantile, With Or Without Nail Dystrophy, Autosomal Dominant .

Foxn1（forkhead box N1）基因又称Hfh11、Fkh19，由该基因编码的蛋白质是叉头家族或“翼状螺旋”转录因子的一部分，称为 叉头框蛋白N1。 Foxn1蛋白是在胸腺上皮细胞中表达的蛋白质，是一种转录因子，其在发育过程中，参与免疫系统调节、代谢，在癌症和衰老中发挥重要的作用。 该基因家族有100多个成员，编码的蛋白质主要是调节胸腺的发育和角化细胞的分化，Foxn1参与 T细胞 成熟和调节基因及抗原的表达。 Foxn1基因 突变纯合子小鼠表现出毛发生长异常和胸腺上皮 …

2024年9月10日 · foxn1是胸腺上皮细胞的关键调控因子，对tec分化和功能至关重要。 FOXN1蛋白在cTEC和mTEC中表达明显，但在aaTEC1和aaTEC2中几乎不表达。 通过分析预测， Foxn1 表达与aaTECs的分化相关， Foxn1 降低会促进向aaTECs分化，而激活 Foxn1 则促使向正常TEC分化。

The FOXN1 gene provides instructions for making a protein that attaches (binds) to specific regions of DNA and regulates the activity of other genes. On the basis of this action, the FOXN1 protein is called a transcription factor.

Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system.

2013年7月12日 · FOXN1 is a master regulator in the TEC lineage specification in that it down-stream promotes transcription of genes, which, in turn, regulate TECs differentiation. In particular, FOXN1 mainly regulates TEC patterning in the fetal stage and TEC homeostasis in …

2013年7月11日 · FOXN1 is a master regulator in the TEC lineage specification in that it down-stream promotes transcription of genes, which, in turn, regulate TECs differentiation. In particular, FOXN1 mainly regulates TEC patterning in the fetal stage and TEC homeostasis in …

Foxn1 is a sensitive and specific marker for thymoma and thymic carcinoma. Mechanisms and signaling pathways by which Foxn1 modulates keratinocyte differentiation in hair follicle and nail apparatus. Molecular and functional consequences of loss of function of Foxn1 protein in skin.

2016年8月22日 · Holländer and colleagues provide a map of genes that are direct targets of the transcription factor Foxn1 in thymic epithelial cells and show that Foxn1 controls genes encoding products...