Fos-related antigen-1 (FRA-1) is a member of activator protein-1 (AP-1) transcription factor superfamily, and FRA-1 is highly expressed in colon cancer, breast cancer, gastric cancer, lung cancer, bladder cancer, and other tumors.

Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene. [5][6] The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1.

2022年6月1日 · The high expression of FRA-1 serves as a signal transduction factor in inflammation. In rheumatoid arthritis (RA), FRA-1 is activated, which directly binds to the Arg1 promoter region, causing Arg1 to be down-regulated. Thereby enrich macrophages, neutrophil and monocytes and promoting inflammation.

2022年8月10日 · Studies have shown that Fra-1 plays a key role in inflammatory lung injury. Fra-1 plays a protective role in pulmonary fibrosis and regulates early fibro genic response. Fra-1 mediates anti-fibrosis effects by regulating pro-inflammatory, pro-fibrotic and fibrotic gene expression in vivo and in vitro (157, 158).

2020年5月8日 · First, we summarize the present knowledge on the FOSL1 transcriptional and epigenetic controls, driving Fra-1 accumulation in a variety of human solid tumors. We also present a model on the...

fra-1: a serum-inducible, cellular immediate-early gene that encodes a fos-related antigen. 1 Department of Molecular Oncology, Roche Institute of Molecular Biology, Nutley, New Jersey 07110. A set of proteins antigenically related to the c-fos protein (Fos) are induced by serum in …

2022年3月14日 · Among components of the AP-1 complex, the FOS-family transcription factor Fra-1, encoded by FOSL1, has emerged as a prominent therapeutic target. Fra-1 is overexpressed in most solid tumors, in response to the BRAF-MAPK, Wnt-beta-catenin, Hippo-YAP, IL-6-Stat3, and other major oncogenic pathways.

2021年3月18日 · The Fos family protein Fra-1 is overexpressed in triple negative breast cancers (TNBCs) where it contributes to tumor aggressiveness. To address its transcriptional actions in TNBCs, we combined transcriptomics, ChIP-seqs, machine learning and NG Capture-C. Additionally, we studied its Fos family kin Fra-2 also expressed in TNBCs, albeit much less.

2015年12月12日 · Our results demonstrate that Fra-1 is an important determinant of the metastatic potential of human colon cancer cells, and that the Fra-1 classifier can be used as a prognostic predictor in colon cancer patients. Keywords: colon cancer, metastasis, Fra-1, in vivo, Wnt. Metastasis is the main reason for many solid tumors to be life-threatening.

2014年11月10日 · In this review, we examine a growing body of work implicating the transcription factor FOS-related antigen 1 (FRA-1) as a central node in tumour cell plasticity networks, and discuss...