2015年7月2日 · The diagonal ear lobe crease (Frank’s sign) is not associated with coronary artery disease or retinopathy in type 2 diabetes: the Fremantle Diabetes Study. Aust N Z J Med 2000;30(5):573–7. 8.

2024年1月31日 · A diagonal ear lobe crease (DELC), or Frank’s sign, is a deep crease or wrinkle extending to the earlobe. Some studies suggest this indicates a greater risk for coronary artery disease,...

Frank's sign is a diagonal crease in the ear lobe extending from the tragus across the lobule to the rear edge of the auricle. [1] The sign is named after Sanders T. Frank. [1] It has been hypothesised that Frank's sign is indicative of cardiovascular disease [2] [3] and/or diabetes. [4]

However, for its feasibility and easy interpretation, Frank’s sign could be considered as a part of physical examination. Keywords: coronary artery disease, coronary syndromes, diagonal earlobe crease, Frank’s sign

2014年8月13日 · A Brief History: Frank’s Sign. In 1973, a physician called Sanders T. Frank had a letter published in the New England Journal of Medicine describing 20 of his patients with an earlobe crease, who were under 60 years old, with angina (chest pain) and proven coronary artery blockages. This study was the first to describe such a possible ...

2024年11月14日 · Frank’s sign refers to a diagonal earlobe crease that can indicate underlying circulatory issues and is a surprisingly accurate predictor of coronary heart disease. Learn what causes Frank’s sign and discover natural and effective ways to support a healthy heart and vascular system.

Frank’s sign refers to a diagonal earlobe crease (DELC). The presence of Frank’s sign has been associated with coronary artery disease. In cases related to a lethal cardiac event, the majority showed high-grade DELC. DELC grade correlated significantly with …

2023年8月16日 · The authors’ initial conclusion was that certain visible signs such as the diagonal earlobe crease, baldness, and xanthelasma, were associated with a greater risk of ischemic heart disease, myocardial infarction, and death, regardless of chronological age and known cardiovascular risk factors.

2021年9月20日 · Frank’ sign or diagonal earlobe crease (DELC) is a diagonal earlobe crease that extends backwards from the tragus at an angle of 45 degree across the lobule to the ear edge of the auricle. It has been described as a dermatological marker for coronary artery disease.

Frank's sign is a diagonal earlobe crease that extends 45° backwards from the tragus to the auricle, which is hypothesised to be a predictor of atherosclerotic disease. Large population prospective study has shown significant association of Frank's sign with increased risks of ischaemic heart disease and myocardial infarctions.

2024年7月9日 · Frank's sign (FS) refers to a diagonal skin fold between the tragus and the outer edge of the earlobe. FS has been identified as an independent variable in coronary artery disease (CAD). Young patients with FS and previous myocardial infarction are still rarely reported in …

Frank’s sign (FS), also known as the diagonal earlobe crease (DELC), refers to a diagonal skin fold between the tragus and the outer edge of the earlobe. It was first described as a predictive dermatological finding of coronary artery disease (CAD) in 1973 by the American pulmonologist Sanders T. Frank [1].

Frank's sign is a diagonal earlobe crease that extends 45° backwards from the tragus to the auricle, which is hypothesised to be a predictor of atherosclerotic disease. Large population prospective study has shown significant association of Frank's sign with increased risks of ischaemic heart disease and myocardial infarctions.

2014年7月1日 · Bilateral earlobe crease (Frank’s sign). ECG showed normal sinus rhythm with no signs of ischemia. He was evaluated with a nuclear stress test, which revealed moderate reversible perfusion defects localized to the lateral wall.

Frank’s sign is a diagonal crease of the ear lobe, supposedly related to cardiac pathology, and has strongly been associated with coronary artery atherosclerosis. A total of 45 consecutive adult patients referred for autopsy in a one-and-a-half-year period were extensively studied.

2024年4月10日 · Can the diagonal earlobe crease (DELC), or Frank's sign, predict heart disease? Here's what cardiologists have to say about the research.

2020年4月14日 · It was first described by Sanders T. Frank, an American physician in 1973 and is a predictive dermatological finding of coronary artery disease. 1, 2 Studies have shown an independent association between Frank’s sign and cardiovascular diseases as well as other vascular diseases (peripheral and cerebrovascular) with a sensitivity of 62.1% and ...

2017年1月2日 · A diagonal earlobe crease (DELC) or Frank's Sign, has been linked with ischaemic heart disease since it was first described in 1973 by Dr. Sanders Frank (Frank, 1973). A classification system has since been developed, outlining the severity of DELC where observed, although its inter-observer reliability has not been demonstrated.

Diagonal ear lobe crease (also known as Frank’s sign) has been traditionally considered as a surrogate marker of coronary and carotid artery atherosclerosis (1). It was first associated with coronary artery disease in an article by Frank published in 1973 (2).

2021年9月20日 · Frank’ sign or diagonal earlobe crease (DELC) is a diagonal earlobe crease that extends backwards from the tragus at an angle of 45 degree across the lobule to the ear edge of the auricle. It has been described as a dermatological marker for coronary artery disease.