2023年1月30日 · The Frank-Starling mechanism plays a role in the compensation of systolic heart failure, buffering the fall in cardiac output to help preserve sufficient blood pressure to perfuse the vital organs. Heart failure caused by the impaired contractile function of the left ventricle causes a downward shift of the left ventricular performance curve.

In honor of these two early pioneers, the ability of the heart to change its force of contraction and therefore stroke volume in response to changes in venous return is called the Frank-Starling mechanism (or Starling's Law of the heart).

2023年7月4日 · Heart failure results when the ventricle is no longer able to provide adequate contraction for a given LVEDV. The Frank-Starling relationship is important for understanding the physiology of heart failure and developing new approaches for treating this disease.

The Frank–Starling law of the heart (also known as Starling's law and the Frank–Starling mechanism) represents the relationship between stroke volume and end diastolic volume. [1] The law states that the stroke volume of the heart increases in response to an increase in the volume of blood in the ventricles , before contraction (the end ...

2023年7月13日 · In a healthy individual, an overloading of blood in the ventricle triggers an increases in muscle contraction, to raise the cardiac output. This is called the Frank-Starling law of the...

The fundamental importance of this Frank-Starling relationship in cardiovascular physiology cannot be overstated. In patients with heart failure (HF), the ability to enhance ventricular filling and ejection in response to stress is characteristically depressed.

A broader physiological importance of our findings is that the underlying cellular basis of Starling's Law of the Heart is an energetically favourable process that yields increased efficiency. Keywords: cardiac energetics, force–length relation, Frank–Starling mechanism, mechanical efficiency

2024年10月6日 · The Frank-Starling mechanism helps buffer the decline in cardiac output experienced during systolic heart failure, which is primarily due to impaired contractile function of the left ventricle. In this condition, the left ventricular performance curve shifts downward.

As the Frank–Starling Law is a vital event for the healthy heart, it is of utmost importance to understand its mechanical basis in order to optimize and organize therapeutic strategies to rescue the failing human heart. The present review is a historic perspective on cardiac muscle function.

2019年7月31日 · The Frank–Starling law (also known as Starling’s law of the heart) states that the strength of ventricular contraction is dependent on the length of the resting fibres. In other words, when all other factors are kept constant, an increase in left ventricular preload causes stroke volume (SV) to increase, without the need for extrinsic ...