2024年12月25日 · FSCN1 (Fascin Actin-Bundling Protein 1) is a Protein Coding gene. Diseases associated with FSCN1 include Inverted Papilloma and Juvenile Xanthogranuloma. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include RNA binding and actin filament binding.

FSCN1蛋白的生理功能. FSCN1可将肌动蛋白微丝（Actin Filaments）捆绑成束，因此它广泛参与各种细胞生理过程，包括细胞粘附（Cell Adhesion）、运动（Cell Motility）、迁移（Cell Migration）和细胞相互作用（Cellular Interactions）的调节。

Fascin actin-bundling protein 1(FSCN1) is over-expressed in adrenocortical carcinoma (ACC) tissue when compared with adrenocortical adenoma and normal adrenal tissue. Over-expression of FSCN1 is associated with the tumor microenvironment and immune signatures in ACCs. Patients with higher expression of FSCN1 are more likely to have worse prognoses.

Fascin is a protein that in humans is encoded by the FSCN1 gene. [5][6][7] FSCN1 has been shown to interact with Low affinity nerve growth factor receptor [8] and PKC alpha. [9] ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. ^ "Mouse PubMed Reference:".

2016年8月22日 · Here we report that zebrafish actin-bundling protein fscn1a is highly expressed in mesendodermal precursors and its expression is directly regulated by the TGF-β superfamily member Nodal. Knockdown...

2021年3月，Hongliang Liu等在Molecular Therapy期刊上发表了《Fascin Actin-bundling Protein 1 in Human Cancer: Promising Biomarker or Therapeutic Target?》的 综述文章，详细介绍了FSCN1基因、蛋白质结构及生理意义，并阐述其在肿瘤细胞中的上调机制及临床意义。 FSCN1基因与蛋白结构. 如图1A所示，人FSCN1基因 (GenBank: NM_003088.4)位于染色体7p22.1，包含5个外显子，长度13840 bp。 人FSCN1基因的核苷酸序列与小鼠 (96.55%)和斑马鱼 (75.76%) …

fscn1是一种肌动蛋白结合蛋白，能够将肌动蛋白丝集成一束。fscn1在几乎所有的转移性肿瘤中高表达，并与大部分肿瘤的不良预后密切相关。fscn1在基底样和三阴性乳腺癌中高度表达。近年来关于fscn1的报道愈发频繁，随着深入研究发现，fscn1除了促进癌细胞的迁移 ...

该基因编码肌动蛋白结合蛋白肌成束蛋白家族的一个成员。 Fascin 蛋白将 F-肌动蛋白组织成平行束，并且是形成基于肌动蛋白的细胞突起所必需的。 编码的蛋白质在细胞迁移、运动、粘附和细胞相互作用中起着关键作用。 已知该基因的表达受几种微小 RNA 的调节，并且该基因的过表达可能通过增加细胞运动性在多种类型的癌症的转移中发挥作用。 该基因的表达也是霍奇金淋巴瘤中 Reed-Sternberg 细胞的标志。 该基因的假基因位于 15 号染色体的长臂上。 [RefSeq 提 …

2021年1月20日 · Fascin actin-bundling protein 1 (FSCN1) is a highly conserved actin-bundling protein that cross links F-actin microfilaments into tight, parallel bundles. Elevated FSCN1 levels have been reported in many types of human cancers and have been correlated with aggressive clinical progression, poor progn …

2022年5月9日 · Fascin actin-bundling protein 1 (FSCN1) is an actin-bundling protein that is capable of inducing membrane protrusions and plays critical roles in cell migration, motility, adhesion, and other cellular interactions. FSCN1 also plays a role in forming and stabilizing filopodia or microspikes, which as …