2013年4月1日 · FSH receptor (FSHR) gene variants have been associated with premature ovarian failure (POF). Genomic DNA from New Zealand women with POF (n = 80) and control women (n = 80) was screened for variants in FSHR exons 7 and 10. FSHR exon 7 variants, including the c.566C>T Finnish founder mutation (p.Ala189Val), were not detected.

2021年10月30日 · FSHR inactivating mutations cause primary or secondary amenorrhea, infertility, and premature ovarian failure (POF), whereas activating mutations can predispose to ovarian hyperstimulation syndrome (OHSS).

2016年2月23日 · Primary ovarian failure (POF) is characterized by hypergonadotropic hypoestrogenic amenorrhea, typically the end result of premature depletion of the follicular pool. This encompasses a spectrum of pathologies and may occur before menarche, as in the descriptive diagnosis XX gonadal dysgenesis, or any time before age 40.

2023年1月31日 · In the case of FSHR, the inactivating mutations can cause primary or secondary amenorrhea, premature ovarian failure (POF), and even infertility, while activating mutations can result in OHSS...

2019年10月19日 · Our findings indicated that FSHR rs6166 polymorphism may serve as a potential genetic biomarker of POI in Asians, but not in other ethnicities. Premature ovarian insufficiency (POI) is currently defined as apparent deterioration of ovarian function before the age of 40 in human beings [1].

2015年4月15日 · Inactivating FSH receptor (FSHR) mutations can affect ovarian function, resulting in variable clinical presentations ranging from primary amenorrhea to premature menopause. FSHR mutations have been largely reported in the Finnish population, but in patients of Asian Indian descent, the incidence of FSHR mutations is extremely rare.

卵泡刺激素fsh是最重要的女性激素之一，通过与其特异性的受体fshr结合，在调控卵泡发育和雌激素合成等过程中发挥不可缺少的作用。目前已有较多关于fsh、fshr与卵巢癌、乳腺癌等肿瘤发生发展的研究报道。

2010年7月1日 · In this study, two polymorphisms of follicle stimulating hormone receptor (FSHR) gene were analysed in the case-control sample using 40 premature ovarian failure (POF) patients, 60 polycystic ovary syndrome (PCOS) patients and 92 healthy controls. All subjects were unrelated Han Chinese from Shanghai.

FSHR inactivating mutations may cause primary or secondary amenorrhea, infertility, and premature ovarian failure (POF), whereas activating mutations can predispose to ovarian hyperstimulation syndrome (OHSS) as a consequence of exogenous FSH administration, or with a spontaneous onset.

FSH receptor (FSHR) gene variants have been associated with premature ovarian failure (POF). Genomic DNA from New Zealand women with POF (n=80) and control women (n=80) was screened for variants in FSHR exons 7 and 10.