2019年5月11日 · BMP15 induced FSHR expression in human granulosa cells through Smad and non-Smad pathways. This mechanism of FSHR induction by BMP15 may be utilized for controlling follicular growth. Follicle-stimulating hormone receptor (FSHR) is essential for follicle growth and ovulation in the ovary.

BMP15 induced FSHR expression in human granulosa cells through Smad and non-Smad pathways. This mechanism of FSHR induction by BMP15 may be utilized for controlling follicular growth.

抑制素B对FSHR表达的抑制作用主要通过Smad通路介导。Smad蛋白是一类信号转导因子，在TGF-β超家族配体信号转导中发挥重要作用。抑制素B与其受体抑制素B受体（INHBR）结合后，激活下游Smad蛋白，包括Smad2和Smad3。

2024年11月1日 · We found that the FecBB mutation enhanced the basal SMAD1/5 signaling activity in COV434 cells, leading to increased expression of FSHR, probably through increased formation of the SMAD1/5–SMAD4 complex to bind to the SBE element, which in turn promotes the binding of USF1 to the regulatory element E -box in the promoter of FSHR.

2022年3月1日 · On the base of above data, we proposed a hypothesis that BMP15 changes the expression of SMAD4 and FSHR, thereby affecting the sensitivity of FSH to granulosa cells (GCs). Knowledge of the BMP15/TβRII/SMAD4 signaling pathway on the effects of FSH is important for a better understanding of the follicular development in mammals.

2024年1月30日 · We employed RNA interference techniques to knock down Smad8 expression in mouse granulosa cells (GCs) to investigate the effects of Smad8 on GC growth and steroidogenesis. Our findings revealed a significant decrease in the proliferative capacity and a substantial increase in the apoptosis rate of GCs after transfection with Smad8 -siRNA for 48 h.

2009年10月1日 · Herein, we investigated the role of Smad3, a critical molecule mediating the intracellular TGFbeta family proteins, in follicle development and the expression of FSH receptors. We found that gonadotropin stimulation could not induce normal ovulation in Smad3 …

2016年11月24日 · SMAD4, the final molecule in transforming growth factor (TGF)- β signaling, bound to the promoter and induced significant downregulation of miR-143 in vitro and in vivo. Activated TGF- β signaling...

In our study, TSA (a histone deacetylase inhibitor) induced FSHR mRNA expression in HGrC1 cells with increasing histone acetylation and transcription factor USF1/2 binding at the FSHR promoter region (Fig. 1). The Smad pathway is linked with histone acetylation BMP signaling .

analyze FSHR expression, histone modifications, and USF1/2 binding at the FSHR promoter region. Histone acetyl transferase (HAT) activity and phosphorylation of Smad 1/5/8 and p38 MAPK were examined with or without BMP15, SB203580, and