Motor neurone disease or MND is a disorder of the nerves that control the body’s motor function. It affects the nerves that go to the muscles in the arms and legs, and that allow people to speak and swallow. It is also known as amyotrophic lateral sclerosis or ALS. About 1 in 10 people with FTD will also develop motor neurone disease.

First, a small but well-documented group of patients present with a full-blown FTD, associated with MND. Second, subtle but characteristic changes in frontal-executive functions and social cognition have been described in non-demented MND patients, often in association with frontal atrophy/hypoactivity on neuroimaging.

Frontotemporal dementia with motor neuron disease (FTD-MND) is a type of frontotemporal lobar degeneration characterized by the insidious onset (between the ages of 38-78 years) of dementia-associated psychiatric symptoms (e.g., personality changes, uninhibited behavior, irritability, aggressiveness), memory difficulties, global intellectual ...

2016年8月27日 · In this Review we assess current knowledge of the pathology, genetics, disease models, and clinical features of frontotemporal dementia-motor neuron disease. Diagnostic criteria are explained and challenges to effective management are outlined.

2014年9月16日 · 额颞叶变性主要包括三种疾病，即行为变异型额颞叶痴呆（bvFTD）以及原发性进行性失语（PPA）的两种类型：非流利性 / 语法错乱性（nfvPPA）和语义性 (svPPA)。 三种类型在微观病理学方面有相互重合的部分，但在行为、执行功能、语言和疾病早期运动功能损害方面表现不尽相同，每一种类型在神经影像学上都有独特的表现。 总体来说，FTLD是由于tau蛋白、TDP-43蛋白、肉瘤融合蛋白（FUS）以及p62双肽蛋白聚集所致。 2011 年发表了对 bvFTD 以 …

up to 15% develop frontotemporal dementia (FTD), either at the same time or after diagnosis of MND; up to 15% of people diagnosed with FTD go on to develop MND. Symptoms of dementia may lead to FTD being diagnosed before movement is affected and MND is diagnosed. There is a wide spectrum of changes in cognition in MND.

Overlap between motor neuron disease (MND) and frontotemporal dementia (FTD) occurs at clinical, genetic and pathological levels, and has been recently strengthened through the discovery of the C9orf72 genetic expansion. MND is now considered to be a multisystem disorder in which cognitive involveme …

What is Frontotemporal dementia with motor neurone disease (FTD/MND)? FTD-MND is a disorder of behaviour, cognition and physical ability. It results from loss of function of the front parts of the brain, which control behaviour and judgement, …

2024年9月10日 · A case of frontotemporal dementia with motor neurone disease (FTD-MND) is presented including diagnosis and inpatient management. This rare form of dementia demonstrates that input from multiple prof...

Frontotemporal dementia with motor neuron disease (FTD-MND) is a type of frontotemporal lobar degeneration characterized by the insidious onset (between the ages of 38-78 years) of dementia-associated psychiatric symptoms (e.g. personality changes, uninhibited behavior, irritability, aggressiveness), memory difficulties, global intellectual ...