2024年12月15日 · Frontotemporal lobar degeneration (FTLD) is the pathological description of a group of neurodegenerative disorders characterized by focal atrophy of the frontal and/or temporal cortices. These results in variable clinical manifestations collectively known as frontotemporal dementia (FTD) syndromes.

2021年1月12日 · By combining AD-RAI and FTDI, an MRI-based decision strategy was further proposed as a promising solution for the differential diagnosis of AD and FTD in clinical practice. The differential diagnosis of frontotemporal dementia (FTD) and Alzheimer’s disease (AD) is difficult due to the overlaps of clinical symptoms.

Structural magnetic resonance imaging (MRI) and (18F)-fluorodeoxyglucose positron emission tomography (FDG-PET) studies have characterized patterns of neurodegeneration and hypometabolism that define the different clinical and pathological variants of FTD, while diffusion tensor imaging (DTI) and resting-state fMRI have improved our understandin...

Objective: To identify overlapping and unique grey (GM) and white matter (WM) signatures within the frontotemporal lobar degeneration (FTLD) continuum, and discriminate likely FTLD-TAU and FTLD-TDP patients using structural and diffusion tensor (DT) magnetic resonance imaging (MRI).

Frontotemporal lobar dementia (FTLD) is a clinically and pathologically complex disease. Advances in neuroimaging techniques have provided a specialized set of tools to investigate underlying pathophysiology and identify clinical biomarkers that aid in diagnosis, prognostication, monitoring, and ide …

2012年4月1日 · The most commonly used neuroimaging approaches to assess FTLD are structural magnetic resonance imaging (MRI) and functional molecular techniques, i.e., single photon-emission computed tomography (SPECT) and positron emission tomography (PET).

Brain magnetic resonance imaging (MRI) studies have demonstrated regional patterns of brain macrostructural atrophy and white matter microstructural alterations separately in the three major subtypes of frontotemporal lobar degeneration (FTLD), which includes behavioral variant frontotemporal dementia (bvFTD), semantic dementia (SD), and ...

2021年9月27日 · 成功确定额颞叶变性（ftld）的新疗法，关键在于能否确定反映这一异质性临床综合征的特定生物过程的有用标志物。 由基因突变引起的病例占FTLD表现的30%，为研究这些过程提供了一个理想的模型，因为可以推断出潜在的病理（即使没有死后确认），有利于设计 ...

Areas covered: This article reviews (1) the neuroimaging studies that propose single-subject MRI classification strategies in symptomatic and pre-symptomatic FTLD, (2) potential practical implications and (3) the limitations of current single-subject data interpretation models.

2022年1月1日 · We apply joint, whole-hemisphere ex vivo MRI at 7 T and histopathology to the study autopsy-confirmed FTLD-Tau (n = 4) and FTLD-TDP (n = 3), relative to ADNC disease-control brains with antemortem clinical symptoms of frontotemporal dementia (n = 2), and an age-matched healthy control.