Frontotemporal lobar degeneration with TPD-43-immunoreactive pathology (FTLD-TDP) is subclassified based on the type and cortical laminar distribution of neuronal inclusions. The relevance of these pathological subtypes is supported by the presence of relatively specific clinical and genetic correlations.

FTLD-TDP (or FTLD-U ) is characterised by ubiquitin and TDP-43 positive, tau negative, FUS negative inclusion bodies. The pathological histology of this subtype is so diverse it is subdivided into four subtypes based on the detailed histological findings:

2022年3月28日 · Amyloid fibrils extracted from brains of patients with frontotemporal lobar degeneration with TAR DNA-binding-protein immunoreactivity (FTLD-TDP) are made up of transmembrane protein 106B.

2019年4月11日 · 额颞叶变性（frontotemporal lobar degeneration, FTLD）是第三大最常见的神经退行性疾病，仅次于阿尔茨海默病和帕金森病。 FTLD通常出现在45～64岁的人群中，伴有行为改变或语言能力的逐渐下降。 作为FTLD的一种亚…

To resolve this issue, the principal authors of the original two papers are now proposing a new classification for FTLD-TDP pathology, the sole purpose of which is to provide a single harmonized system that replaces the two currently in use.

2023年8月2日 · Here we report the cryo-electron microscopy structures of assembled TDP-43 from the brains of three individuals with the most common type of FTLD-TDP, type A. TDP-43 formed amyloid filaments...

Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) can typically be categorized into one of four distinct histopathologic patterns of TDP-43 pathology, types A to D. The strength of this histopathologic classification lies in the association between FTLD-TDP subtypes and various cli …

2019年9月1日 · Heterozygous loss-of-function mutations in the GRN gene lead to progranulin (PGRN) haploinsufficiency and cause frontotemporal lobar degeneration with TDP-43 pathology type A (FTLD-TDP type A). PGRN is a highly conserved, secreted glycoprotein and functions in the central nervous system as a key mod …

2023年8月10日 · Frontotemporal lobar degeneration (FTLD) is one of the most common causes of early-onset dementia and presents with early social–emotional–behavioural and/or...

FTLD 的主要亚型以包含 TDP-43 的神经元包涵体为特征，称为 FTLD-TDP，约占所有 FTLD 病例的 50%。 根据 TDP-43 包涵体的形态和神经解剖分布，FTLD-TDP 进一步分为 A 型至 E 型；每种类型都与不同的临床症状相关。