2021年3月16日 · Our findings uncover the Xbp1s-FoxO1 axis as a pivotal mechanism in the pathogenesis of cardiometabolic HFpEF and unveil previously unrecognized mechanisms …

2024年8月27日 · 巨噬细胞Foxo1缺失（Foxo1M-KO）改善了HFD肝脏中的肝炎、脂肪肝和纤维化，减少了HFD肝脏中STING（stimulator of IFN genes）、TBK1（TANK-binding kinase 1） …

FOXO转录因子 家族通过调节基因表达参与细胞的生理事件，包括凋亡、细胞周期控制、葡萄糖代谢、氧化应激抵抗和寿命延长。 FOXO蛋白的一个核心调控机制是在胰岛素或多种生长因子刺 …

2023年9月1日 · FOXO1 can regulate the lipogenesis by affecting the transcriptional activity of CD36 and STEAP4. Intramuscular fat content is closely related to the quality of beef, where …

2025年2月15日 · In this study, we investigated the role of FOXO1 in PFOS-induced glycolipid metabolism disorders. Our findings indicate that PFOS exposure increases hepatic Ac-FOXO1 …

Forkhead box O1 (FoxO1) is involved in lipid metabolisms. However, its role in chronic stress-related nonalcoholic fatty liver disease (NAFLD) is unclear. The scientific premise of our study …

FoxO1 Forkhead proteins are major targets of insulin action. The insulin signaling through FoxO1 plays an important role in regulating hepatic microsomal triglyceride transfer protein (MTP) …

2021年5月13日 · FoxO1是叉头转录家族O亚族的一类代谢性调节因子，通过磷酸化、乙酰化、泛素化修饰等方式调控多种基因的表达。FoxO1可以结合于PDX-1基因的启动子上，通过抑制其 …

The expression of lncRNA enhancing endothelial nitric oxide synthase expression (LEENE), Forkhead box O1 (FoxO1) and ATP binding cassette transporter A1 (ABCA1) was evaluated …

2015年12月18日 · FoxO1 has emerged as a key player in insulin action and carbohydrate metabolism. FoxO1 targets PEPCK and G6Pase genes for trans-activation in the liver for …