2024年5月27日 · JNK：MAPK超家族中的应激活化蛋白激酶及其生物学功能. JNK是促分裂原活化蛋白激酶(mitogen-activated protein kinase，MAPK)超家族成员之一。此外，由于JNK可被多种细胞外应激信号激活，其也被称为应激活化蛋白激酶(stress-activated MAP kinase，SAPK)。

JNK是促分裂原活化蛋白激酶(mitogen-activated protein kinase，MAPK)超家族成员之一。此外，由于JNK可被多种细胞外应激信号激活，其也被称为应激活化蛋白激酶(stress-activated MAP kinase，SAPK)。JNK家族共有三个JNK基因：JNK1、JNK2和JNK3，它们通过剪接产生异构体JNK1、JNK2和JNK3。

2024年8月5日 · Here we reveal that intracellular pH (pHi) is a significant component of the JNK network and defines signal response to specific stimuli. We show pHi regulates JNK activity in response to cell...

应激活化蛋白激酶 (sapk)/jun 氨基末端激酶 (jnk) 是 mapk 家族的成员，可由各种不同环境应激、炎症细胞因子、生长因子以及 gpcr 激动剂激活。 应激反应信号经 Rho 家族（Rac、Rho、cdc42）的小分子 GTP 酶传递到这个级联。

JNK, also known as stress-activated protein kinases (SAPK), represents a subfamily of the canonical MAPK signal transduction pathway [1], which along with cyclin-dependent kinases (C DKs), g lycogen synthase kinase 3 (G SK3), and CDK-like kinases (C LKs), constitutes a larger family referred to as the CMGC Ser/Thr group kinases [1, 2, 3].

2007年5月14日 · G proteins provide signal-coupling mechanisms to heptahelical cell surface receptors and are critically involved in the regulation of different mitogen-activated protein kinase (MAPK) networks. The four classes of G proteins, defined by the G(s), G(i), G(q) and G(12) families, regulate ERK1/2, JNK, …

2024年10月2日 · JNK is involved in the TGF-β pathway, which plays an important part in cell activation, proliferation, and immune regulation. Evidence indicates that JNK can regulate the TGF-β signaling cascade through various mechanisms, including phosphorylation of Smads [41].

JNK is an important transducing enzyme that is involved in many facets of cellular regulation including gene expression, cell proliferation and programmed cell death. The activation of JNK pathways is critical for naturally occurring cell death during development as well as for pathological death associated with neurodegenerative diseases.

2007年5月1日 · JNK are multifunctional kinases involved in many physiological processes. The JNK pathway has been shown to play a major role in apoptosis in many cell death paradigms and its association with...

我们得出结论，无论 Bid 和 Bim 激活如何，Bax 的 JNK 依赖性调节对于介导细胞色素 c 的凋亡释放都是必不可少的。 JNK 影响线粒体的信号传导机制对于启动细胞凋亡至关重要。 在这里，我们表明不存在 JNK 可以部分抵抗重金属镉的毒性作用。 经历死亡的野生型和 jnk-/- 成纤维细胞都表现出细胞溶质细胞色素 c，但与野生型细胞不同，缺乏 JNK 的成纤维细胞不显示增加的半胱天冬酶活性和 DNA 片段化。 没有细胞凋亡与 Bax 激活的特定缺陷相关。 我们得出结论，无论 Bid …