Many mammal cells, such as this 9x H neuron, remain permanently or semipermanently in G 0. The G0 phase describes a cellular state outside of the replicative cell cycle. Classically [when?], cells were thought to enter G 0 primarily due to environmental factors, like nutrient deprivation, that limited the resources necessary for proliferation.

2023年5月23日 · Lastly, we demonstrate that G0 arrest underlies unfavourable responses to various therapies exploiting cell cycle, kinase signalling and epigenetic mechanisms in single-cell data. We propose a G0 arrest transcriptional signature that is linked with therapeutic resistance and can be used to further study and clinically track this state.

2025年2月8日 · Among its phases, G0 is where cells exit the active cycle, entering a quiescent state. Understanding this phase is crucial due to its roles in tissue maintenance and cellular differentiation, influencing how cells respond to damage or stress and their potential to reenter the cycle for division.

2024年11月23日 · Cells in G 0 phase are not actively preparing to divide. The cell is in a quiescent (inactive) stage that occurs when cells exit the cell cycle. Some cells enter G 0 temporarily until an external signal triggers the onset of G 1. Other cells that never or rarely divide, such as mature cardiac muscle and nerve cells, remain in G 0 permanently.

In addition to these four proliferative phases, cells may also “exit” the proliferative cell cycle into a state of cell cycle arrest, often referred to as G0. While arrested, cells still perform many essential cellular functions including metabolism, secretion, transcription, and translation.

细胞可以退出细胞周期，进入不分裂阶段（g0 期），进入后，可以通过适当的激活重新进入细胞周期。 可使用以化学计量法与 DNA 结合的染料与细胞共同孵育，检测细胞内的DNA含量。

2014年2月6日 · In this study, a fusion protein consisting of mVenus and a defective mutant of CDK inhibitor, p27 (p27K −) was shown to be able to identify and isolate a population of quiescent cells and to...

2023年11月21日 · The G0 phase, also known as the resting phase, is the phase of the cell cycle during which a cell is neither dividing nor preparing to divide. During this period the cell performs...

休眠细胞暂不分裂,但在适当的刺激下可重新进入 细胞周期,称G0期细胞,如 淋巴细胞 、肝、肾细胞、休眠的 种子细胞 等。 也称休眠细胞。 这些细胞可暂时脱离细胞周期，不进行增殖，但在适当刺激下可重新进入细胞周期。 G0期细胞是指休眠细胞暂不分裂，但在适当的刺激下可重新进入细胞 …

In G 0 phase, cells respond to extracellular signals by entering the G 1 phase of the cell cycle. However, prior to transiting into the late G 1 phase, they must traverse the growth-factor-dependent restriction point.