G1/S transition - Wikipedia
The G1/S transition is a stage in the cell cycle at the boundary between the G1 phase, in which the cell grows, and the S phase, during which DNA is replicated. [1] It is governed by cell cycle …
Control of cell cycle transcription during G1 and S phases
The accurate transition from G1 phase of the cell cycle to S phase is crucial for the control of eukaryotic cell proliferation, and its misregulation promotes oncogenesis. During G1 phase, …
Cancer takes many paths through G1/S - Cell Press
2023年11月10日 · Recent data indicate considerable heterogeneity in cancer cycles as controlled by distinct cyclin-dependent kinase (CDK) and cyclin complexes. Adaptation and unexpected …
Integrating Old and New Paradigms of G1/S Control - Cell Press
2020年10月15日 · The G1/S transition of the cell cycle is a critical control point for cell proliferation and a target of new cancer therapies. Rubin et al. describe the existing molecular …
G1/S 检查点 | Cell Signaling Technology
主要的 G1/S 细胞周期检查点控制着真核细胞是否通过 G1 期进入 DNA 合成 S 期。 两种细胞周期激酶复合体，CDK4/6-周期素 D 和 CDK2-周期素 E 共同协作，以解除对含有视网膜母细胞瘤 …
Integrating old and new paradigms for G1/S control - PMC
The Cdk-Rb-E2F pathway integrates external and internal signals to control progression at the G1/S transition of the mammalian cell cycle. Alterations in this pathway are found in the vast …
细胞周期通路 | Cell Signaling Technology
在 g1 末期被周期素依赖性激酶 (cdk) 磷酸化的 rb 会诱使 rb 分裂，并允许 e2f 介导的 s 期促进基因的转录。 作为对上游信号的反应，INK4 和 Kip/Cip 家族抑制剂会控制 CDK 活性，并防止其 …
A unified model for the G1/S cell cycle transition - PubMed
2020年12月16日 · To control CP1-3, dedicated hubs integrate the antagonistic mitogenic and DNA damage signals, regulating the stoichiometric cyclin: CDK inhibitor ratio for ultrasensitive …
G1 和 S 期细胞周期转录的控制,Nature Reviews Molecular Cell …
在 g1 期，生长依赖性细胞周期蛋白依赖性激酶 (cdk) 活性促进 dna 复制并启动 g1 到 s 期的转变。 CDK 激活启动正反馈循环，进一步增加 CDK 活性，这通过诱导全基因组转录变化使细胞分裂。
unified model for the G1/S cell cycle transition | Nucleic Acids ...
2020年11月9日 · The six conditions we set out can be used as a framework to identify new factors that integrate mitogenic and DNA damage signalling for control of the stoichiometric cyclin: …